Fc-fusion proteins in therapy: an updated view. Curr Med Chem, 2017, 24(12): 1228-1237.Jafari R, Zolbanin NM, Rafatpanah H, Majidi J, Kazemi T. Fc-fusion proteins in therapy: an updated view. Curr Med Chem. 2017;24:1228- 37. doi:10.2174/0929867324666170113112759. PMID:28088904...
参考资料 1. A. Beck and J. M. Reichert, Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies, 2011. 2. A. Goyon, M. Excoffier, M.-C. Janin-Bussat, B. Bobaly, S. Fekete, D. Guillarme and A. Be...
This membrane format is disposable, has high throughput, and has good efficiency in removing negatively charged impurities such as nucleic acids, virus, and if needed, endotoxin, and some host cell proteins. The pI of the product is variable, depending on the degree of sialylation. However, ...
Chen X, Liu YD, Flynn GC (2009) The effect of Fc glycan forms on human IgG2 antibody clearance in humans. Glycobiology 19:240–249 Article CAS PubMed Google Scholar Chirmule N, Jawa V, Meibohm B (2012) Immunogenicity to therapeutic proteins: impact on PK/PD and efficacy. AAPS J 14...
Fc proteins interact with FcRn, resident within endosomes. Endosomes containing FcRn direct the Fc fusion proteins back to the plasma membrane, releasing them into circulation in a pH-dependent manner,25 thereby avoiding lysosomal degradation. This recycling approach has been used successfully to extend...
As reported previously, bi-FSTL3-Fc bound to recombinant activin A, GDF8, and GDF11 proteins in vitro, while the binding affinity to BMP9 was low (Figures 1C–1G). It is of note that biotinylation might slightly disrupt FSTL3 ligand binding. However, concerning BMP9, targets of ...
Total glucosides of paeony inhibit the proliferation of fibroblast-like synoviocytes through the regulation of G proteins in rats with collagen-induced arthritis. Int Immunopharmacol. 2014;18:1–6. Article CAS Google Scholar Zhu L, Wei W, Zheng YQ, Jia XY. Effects and mechanisms of total ...
These TNFR2 agonist-Fc fusion proteins, which have bivalent structures, are novel Treg expanders. Regulatory T cells (Tregs) are a subpopulation of T lymphocytes that have immunosuppressive effects on other immune cells. Tregs exist in mammals such as mice or humans and control immune responses ...
Preferably, the Fc fusion protein of the invention is a dimer. The dimer preferably forms via a disulfide bond between free cysteine residues in the hinge region of two monomeric Fc fusion proteins of the invention.Inventors: Alvarez, Juan (Lincoln, MA, US) Moustakas, Demetri T. (Belmont,...
In this alignment a formatting scheme is used to highlight regions of similarity between the putative receptors, the Fc-fusion protein and the Fc constant region: Boxed type is used to indicate regions of identical sequence between the variant proteins and the p75-NTR; Single underlining is used...