Role of the Fc portion of antibody in immune regulation. In Cells of Immunoglobulin Synthesis. B. Pernis and H. J. Vogel, editors. Academic Press, Inc., New York. 223.W. O. Weigle and M. A. Berman, Role of the Fc portion of antibody in immune regulation, in:“Cells of ...
(fc), containing the H chain constant region. IgG antibody have enormous therapeutic potential and the Fc is for the development of therapeutic antibody. Although the antibody site is located in the terminal end of the human IgG molecule (part of the Fab fragment), the Fc portion has various...
In this system, monocytes but not lymphocytes act as effector cells and the amount of killing observed correlates with the number of monocytes in the mononuclear cell effector population. The results showed that MMADCC requires the Fc portion of the antibody. However, as seen in the WAS ...
SEVERAL kinds of cells involved in immunity can bind antibody or immune complexes through surface receptors which interact with the Fc portion of IgG (Fc receptors). The expression of Fc receptors on mononuclear phagocytes (monocytes/macrophages) can undergo changes in response to various stimuli ...
[22]. One hypothesis was that membrane-distal epitopes allow better access to the Fc portion of the antibody for more efficient cross-linking. Here, we show that APX005M, which binds to the CD40L binding site and effectively competes with CD40L, elicits more potent agonistic activity than ...
If B cells recognize their cognate antigen in the spleen a portion of them switch the expression of their B-cell receptor from IgM to other isotypes such as IgG, IgA or IgE. The decision of which isotype is generated is strongly influenced by the specific cytokine milieu and other cells su...
US5189014 * 1991年6月7日 1993年2月23日 Cowan Jr Fred M Administering a dose of one Fc reagent selected from exogenous polypeptide having atleast one site binds to the Fc-portion of said antigen-antibody immune complex being susceptible to such binding; immunotherapy...
The whole IgG form of antibodies is suitable for the majority of immunodetection procedures and is the most cost effective. Based on immunoelectrophoresis and/or ELISA, the antibody reacts with the Fc portion of human IgG heavy chain but not with the Fab portion of human IgG. No antibody ...
Most mAbs display target mediated drug disposition (TMDD), which can have significant consequences on the study designs of preclinical and clinical studies. The PK of mAb can also be influenced by anti-drug antibody (ADA) response and off-target binding, which require careful consideration during ...
ADCC can be mediated through effector cells such as, for example, natural killer (NK) cells, by binding of FcR expressed on the surface of the effector cell to the Fc portion of the antibody which itself is bound to the foreign antigen or cell. Because of the central role that FcRs ...