Amplicon library was then sequenced on a MiSeq sequencing system (Illumina, San Diego, CA, USA) and the data were analyzed by MiSeq Reporter. Reads were aligned to NCBI37/hg19 assembly using the BWA Multi-Vision software package with SNPs and indels identified using the SOAPsnp software and ...
Specifically, we show that an immobilized form of Fbs1 is able to bind to both high-mannose and complex N-glycans regardless of the presence or absence of a1,6-linked fucose attached to the innermost GlcNAc residue. In low ionic strength buffer, Fbs1 preferentially binds to high-mannose N-...
the drug could also find applications in more prevalent neurological conditions. The rare disease Arialys plans to treat first is anti-NMDA receptor encephalitis (ANRE). It’s a form of encephalitis caused by autoantibodies produced by B cells, a type of immune cell. La Jolla, California-based...
Glycosylation is one of the most common and structurally diverse forms of post-translational modification of eukaryotic proteins. It is estimated that >50% mammalian proteins possess some form of glycosylation and each mammalian cell may contain >10 million N- or O-linked glycans attached to protein...