Fibrous cortical defect has not been described in animals, and examination of a large number of radiographs of young dogs has not shown features resembling this rather common condition in humans. The tumor is less common than osteosarcoma or chondrosarcoma, perhaps accounting for 4鈥 10 percent of...
Additionally, palmitate increases the expression and secretion of tumor necrosis factor (TNF)-α and interleukin (IL)-10 [64], [65] and activates toll-like receptor (TLR) signaling in murine adipocytes [66], [67], [68] and macrophages [65], [66], [68], [69], leading to nuclear ...
hFAS is highly expressed in a number of cancers, with low expression observed in most normal tissues. Although normal tissues tend to obtain fatty acids from the diet, tumor tissues rely on de novo fatty acid synthesis, making hFAS an attractive metabolic target for the treatment of cancer. ...
The KGN cells, which are derived from a stage-3 diagnosed granulosa cell tumor removed from a 63-year-old Japanese woman in 1984, are believed to have originated from a dominant follicle at the antral or pre-antral stage. These cells bear functional FSH receptors and share other similarities...
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. For NAFL, we utili
Thus, although the evidence linking chronic LC-FFA exposure to β-cell loss has validity for rodent cells maintained in tissue culture, it is much less clear that a similar situation obtains in humans. Therefore, in the present study, we have examined the effects of a range of LC-FFA on ...
It is concluded that the observed inhibition of tumor growth by the vaccenic acids may be mediated by their effect(s) on the PI cycle which may be associated with their incorporation into membrane lipids. 展开 关键词: Humans Tumor Cells, Cultured Cell Membrane Colonic Neoplasms Fatty Acids Cell...
(tumor necrosis factor-and interleukin-6) and of oxygen reactive species.Further strengthening the results of the in vitro studies,both animal models and human intervention trials,showed a beneficial effect of n-3 PUFAs on the severity of NAFLD as expressed by laboratory parameters and imaging ...
It is well known that malignant cells circulate in the bloodstream of patients with solid tumors. However, the biological significance of circulating tumor... S Mocellin,U Keilholz,CR Rossi,... - 《Trends in Molecular Medicine》 被引量: 410发表: 2006年 The effect of human C apolipoproteins...
It was recently reported that saturated fatty acids, such as palmitic acid and stearic acid, induce the production of the inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin (IL)-6 (Huang et al., 2011). Because such induction is not observed with PUFA, saturated fatty ...