His steps were the short and shuffling ones of a man advanced in years and in fatty degeneration, but of a sudden they stopped beneath my very eyes. View in context Little children ran after us, crying: "Hey, mister, ain't you hungry?" And one woman, nursing a child at her breast,...
breastcancerdietalpha-linolenicaciddocosahexaenoicacidn-3/n-6ratioadiposeExperimental studies have indicated that n-3 fatty acids, including alpha-linolenic acid (18:3 n-3) and long-chain n-3 polyunsaturated fatty acids inhibit mammary tumor growth and metastasis. Earlier epidemiological studies have ...
This review presents the evidence for the hypothesis that dietary linoleic acid and its metabolic derivative arachidonic acid enhance the metastatic process in breast cancer. Key biochemical events are eicosanoid biosynthesis and protein kinase C activation, both of which are involved in tumor cell ...
Our data revealed an increase in fatty acids in MCF-7 and MDA-MB-231 cells upon resveratrol treatment. Interestingly, we also found an increase in the expression of both flotillin-1 and flotillin-2 in breast tumor cells after treatment. Resveratrol also induced changes in the pattern of ...
1f). HCC tissues were further divided into FABP5-high or HIF-1α-high and FABP5-low or HIF-1α-low tissues; we found that elevated FABP5 and HIF-1α expression in the tumor was associated with poor tumor-free survival in HCC patients (Fig. 1g). Collectively, these data indicate ...
Studies in rodent models find that increasing the ratio of total omega-3:omega-6 in feed to >1 (usually with EPA + DHA between 8 and 25% of calories) reduces mammary cancer incidence and multiplicity by 20 to 35% [22,32,37-41].Reductions in tumor incidence have been observed in...
Leptin has been shown to promote breast tumor growth via autophagy induction. Here, we demonstrate that SREBPinduction downstream of leptinヾependent autophagy activation triggers a profound reprogramming in fatty acid metabolism. This metabolic reprogramming increases ATP production and fuels breast cancer...
Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation and cell-extrinsic influences, incl...
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma. Cancer Gene Ther. https://doi.org/10.1038/s41417-022-00510-0 (2022). Dudek, M. et al. Auto-aggressive CXCR6(+) CD8 T cells cause liver ...
Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling Article Open access 27 February 2024 Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer Article Open access 04 Marc...