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Standards of medical care in diabetes. Diabetes Care. 2018;42(suppl 1):S1-S194. Andrieu S, Guyonnet S, Coley N, et al; MAPT Study Group. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults ...
The term non-alcoholic fatty liver disease was coined in 1980, but observations of people with too much fat in their liver cells and no other cause of steatosis (e.g. alcohol consumption) were already being made in the 19th century.15 At the time, doctors did not understand the metabolic...
In the long-term, offspring of mothers subjected to PND are prone to defects in cognitive development in childhood, have a higher risk to display depressive behavior in adolescence and be involved in criminal activities in adulthood9,10. The treatment of PND is a clinical dilemma. Almost all ...
[46,47], whereas a recent study discovered α-syn aggregates in the ENS of IBD patients [48]. In addition, IBD patients have a higher risk of PD [49]. The long-term intestinal inflammatory state can induce abnormal α-syn aggregation and aggregation of α-syn can also aggravate ...
46 After 8 weeks, fecal microbiota of stool samples from the colonized mice was found to cluster with the stool sample from their respective donor (PERMANOVA R2 = 0.39, p = 0.0001) (Figure S4A). Using an UpSet plot to evaluate how many amplicon sequence variants (ASVs) were shared between...
By contrast, short-term endurance exercise has little effect on gut microbiota composition in older individuals. Five weeks of endurance exercise, for example, caused few changes in older men’s microbiome profile (i.e., increased Oscillospira and decreased Clostridium difficile)20. Furthermore, a ...
Furthermore, PAHSAs improve metabolic status in mice (data not shown), reinforcing the safety and potential beneficial value of long-term use of these novel lipids. Some metabolic effects of PAHSAs are mediated through GPR120, a known long-chain fatty acid lipid sensor (8). Pro-inflammatory ...
and to further differentiate responders from low/non-responders after intervention. Taken together, our study with relatively long-term intervention provides both statistical and sample-specific network insights into the complex gut microbial ecosystem in patients with NAFLD and glucose metabolism impairment...
Participants collected fecal samples at home using a collection kit containing sampling paper, a sterile container with a spoon and gloves (EasySampler Stool Collector, GP Medical Devices Aps, Denmark) at day 0, 42 and 112. The participants scored their fecal sample consistency according to the Br...