A and B, SMSr immunostaining was performed on liver sections from human NASH patients and controls. Quantification was shown by fluorogram. C and D, NASH patient and control plasma PE and PC were measured. PE and PE/PC quantification was shown by fluorogram. E and F, NASH patient and ...
Two children with liver failure who had defective fatty acid uptake measured in patient fibroblasts have been described, but molecular analysis failed to find a causative mutation in candidate genes. Although their illness had many other features of FAOD there was conspicuously little steatosis.28 ...
1) [312]. Then add to this the very recent report that the plasma membrane exhibits dramatic glycerophospholipid unsaturation asymmetry with the cytoplasmic leaflet being approximately twofold more unsaturated than the exoplasmic leaflet [313]. Adding further complexity is the role of subdomain ...
To date, few studies have assessed the rate of long-chain free fatty uptake in cancer cells. One notable study reported that malignant prostate cancer tissue had higher fatty acid uptake rates compared to patient-matched benign tissue [52]. Interestingly, the same authors reported that near-compl...
(IO conformation). The opening to the outer peroxisomal leaflet may offer a putative portal for the acyl chain of bound substrates to extend outside the cavity into the surrounding membrane space. The ATP-dependent switch to the OO conformation could entail a lateral movement of the acyl chain...
Then add to this the very recent report that the plasma membrane ex- hibits dramatic glycerophospholipid unsaturation asymmetry with the cytoplasmic leaflet being approxi- mately twofold more unsaturated than the exoplasmic leaflet [313]. Adding further complexity is the role of subdomain features of...
FATP1ACSVL4SLC27A1 WAT, BAT, skeletal muscle, heart Reduced fatty acid uptake into muscle and adipose tissue; increased fatty acid uptake into liver, reduced thermogenesis FATP2ACSVL1SLC27A2 Liver, kidney Protection from high-fat diet-induced hepatic steatosis, decreased oxidation of very-long-...
MRI of the brain of the patient and his father, who also presented with ataxia but no skin pathology, showed pontine and cerebellar atrophy as well as the hot cross bun sign as previously reported in patients with SCA34 with p. L198F and p. W246G ELOVL4 mutations (35, 36, 65). ...
FABPpm is peripherally bound at the outer leaflet of the plasma membrane and has a modest transport capacity. The sequence of FABPpm protein is identical to the mitochondrial aspartate aminotransferase. FABPpm probably cooperates with FAT/CD36, which is an integral membrane protein with multiple fun...