Two children with liver failure who had defective fatty acid uptake measured in patient fibroblasts have been described, but molecular analysis failed to find a causative mutation in candidate genes. Although their illness had many other features of FAOD there was conspicuously little steatosis.28 ...
1) [312]. Then add to this the very recent report that the plasma membrane exhibits dramatic glycerophospholipid unsaturation asymmetry with the cytoplasmic leaflet being approximately twofold more unsaturated than the exoplasmic leaflet [313]. Adding further complexity is the role of subdomain ...
To date, few studies have assessed the rate of long-chain free fatty uptake in cancer cells. One notable study reported that malignant prostate cancer tissue had higher fatty acid uptake rates compared to patient-matched benign tissue [52]. Interestingly, the same authors reported that near-compl...
(IO conformation). The opening to the outer peroxisomal leaflet may offer a putative portal for the acyl chain of bound substrates to extend outside the cavity into the surrounding membrane space. The ATP-dependent switch to the OO conformation could entail a lateral movement of the acyl chain...