It is estimated that by 2020, NASH will become the leading cause of the need for liver transplants, surpassing hepatitis and alcoholic liver disease. The findings are an expansion of a previous study from Lin's lab, which showed Nrg4 could prevent the liver from converting sugar into fat, ...
TPC2-deficient mice are highly susceptible to hepatic cholesterol overload and liver damage consistent with non-alcoholic fatty liver hepatitis. These findings indicate reduced metabolic reserve of hepatic cholesterol handling. Our results suggest that TPC2 plays a crucial role in trafficking in the ...
Coagulation in Liver Disease: A Guide for the Clinician - ScienceDirect The human hemostasis system is complex and poorly understood after decades of intense scientific study. Despite multiple defects in routine coagulation lab... PG Northup,SH Caldwell - 《Clinical Gastroenterology & Hepatology the ...
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. For NAFL, we utilized 9,491 clinical cases and proton density f...
16 These findings suggest metastatic mechanisms may differ owing to heterogeneity of the tumor microenvironment (TME) in fatty liver, which may explain diverse responses to cancer therapies among patients. As such, disease management for liver metastasis may differ in patients with or without fatty ...
These findings may result from the lower n-3 intake common in the United States, but that low intake is an important consideration. Current recommendations have people consuming ratios between 7:1 and 11:1, which does not match findings that lower ratios are better, especially if there is ...
The present invention relates to a functional health food composition containing a Dolichos lablab L. extract as an active ingredient for preventing or alleviating non-alcoholic fatty liver diseases (NAFLD), and confirmed that the Dolichos lablab L. extract, which is the active ingredient in the ...
133,134 Taken together, these findings imply that the intake of sugar-sweetened beverages and foods high in added sugar should be reduced as part of the treatment of NAFLD. Other aspects of dietary composition Adequate amounts of fruits and vegetables may reduce the risk of NAFLD,135 attributed...
Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive v
Our findings uncovered a previously unappreciated link between omega-6 HUFAs and male steroid hormone production in the male reproductive system. Results FADS2 is highly expressed in Leydig cells HUFAs are believed to be biosynthesized from essential fatty acids mainly in the liver, where their ...