The HTWP group had a higher prevalence of metabolic syndrome (84.2%), FP (10.4%), fatty liver (64.5%), and hypertension (15.8%) than the other three phenotype groups. The occurrence rate of HTWP and the median WTI were significantly higher in participants with FP than in those without ...
Food and Drug Administration (FDA) issued a warning about kava kava, a supplement used to treat anxiety, because of its potential negative side effects such as severe liver damage. Yet, people who take supplements are more likely to trust companies and individuals promoting alternative treatments ...
Not Available Withdrawn Treatment Total Parenteral Nutrition-Induced Cholestasis 1 somestatus stop reason just information to hide 4 Active Not Recruiting Prevention Diabetes Mellitus 1 somestatus stop reason just information to hide 4 Completed Prevention Cirrhosis of the Liver / Liver Cancer 1 somestatu...
Axial (A) and coronal (B) images of the liver provide anatomical information, but are unable to provide any clarity regarding the underlying pathophysiologic process. Results sheet (C) shows the complexity of this individual’s disease. In a pattern characteristic of AIH, the spread of fibro...
3C). Liver tissue verification for the mRNA levels was also confirmed (Supplementary Fig. 3D). Subsequently, we generated two mouse models of HCC using the chemical carcinogen DEN only, or in combination with CCl4 (DEN + CCl4) (Fig. 1A). Both male and female mouse HCC models were ...
The liver is the single most important regulator of metabolic homeostasis at the organismal level. That makes metabolomics an indispensable tool for capturing an integrative profile of an individual’s liver function. As the incidence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatoh...
The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50 ng/L glyphosate equiva
Zivkovic AM, German JB, Sanyal AJ. Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am J Clin Nutr. 2007;86:285–300. CASPubMedGoogle Scholar Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006...
To determine if PLIN5 translocation is dependent on ATGL-catalyzed lipolysis, we knocked down Atgl in mouse primary hepatocytes and liver as described previously (Ong et al., 2011). PLIN5 was still able to translocate to the nucleus in response to cAMP (cells) or overnight fasting (livers)...
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases globally. Pharmacological treatments for NAFLD are still limited. Silymarin, a compound extracted from Silybum marianum, is an herbal supplement traditionally used in folk medicine for liver disorders. It has been ...