nutrients Article Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis Chien-Chao Chiu 1, Yung-Hao Ching 2, Yen-Peng Li 3, Ju-Yun Liu 4, Yen-Te Huan...
Humans may have evolved on a diet with a relatively balanced ratio of n-6:n-3 PUFAs, but in the average modern Western diet this ratio may be 10:1 or higher3. Given the broadly opposing pro- and anti-inflammatory effects of their lipid mediators1, the balance of n-6 and n-3 fatt...
Consistent with this, Psd3 downregulation by antisense oligonucleotides in vivo protects against FLD in mice fed a non-alcoholic steatohepatitis-inducing diet. Thus, translating these results to humans, PSD3 downregulation might be a future therapeutic option for treating FLD. Fatty liver disease (FLD...
Weight reduction for non-alcoholic fatty liver disease. Cochrane Database Syst Rev. 2011;(6):CD003619.PubMedGoogle Scholar 20. Paris T, George ES, Roberts SK, Tierney AC. The effects of diet and lifestyle interventions on insulin resistance in patients with nonalcoholic fatty liver disease:...
Non-alcoholic fatty liver disease (NAFLD) is usually a silent disease that occurs in a very high proportion of people with features of the metabolic syndrome, including overweight, insulin resistance and type 2 diabetes. Because obesity and type 2 diabetes are now extremely common in Westernised...
Deletion of Cd36 in the liver attenuates high-fat diet (HFD)-induced fatty liver due to decreased hepatic fatty acid uptake (Wilson et al., 2016). Humans with CD36 deficiency also show defects in fatty acid uptake in muscle and adipose tissues (Hames et al., 2014). Notably, CD36 is ...
Study participants in the included cohorts (a) were >18 years old, (b) had no major medical diagnoses (prior myocardial infarction, prior stroke, severe active cancer, severe renal disease, severe liver, or lung disease), (c) were not taking supplemental fish oil, and (d) did not die ...
Non-alcoholic fatty liver disease (NAFLD) is a common, progressive liver disease strongly associated with the metabolic syndrome. It is unclear how progression of NAFLD towards cirrhosis translates into systematic changes in circulating proteins. Here, we provide a detailed proteo-transcriptomic map of...
Among the dietary groups, mice fed a high-butter diet containing casein showed the most profound liver TG accumulation. However, liver TG concentrations of mice fed an HF (high-safflower oil and high-butter) diet containing β-conglycinin were markedly decreased. The mechanisms underlying the ...
nutrients Article Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis Chien-Chao Chiu 1, Yung-Hao Ching 2, Yen-Peng Li 3, Ju-Yun Liu 4, Yen-Te Huang 4, Yi-Wen Huang 5...