Conclusions: Older female patients with isolated elevated alkaline phosphatase and risk factors for NAFLD should be evaluated for evidence of significant steatohepatitis. 展开 关键词: nonalcoholic fatty liver disease NASH alkaline phosphatase DOI: 10.1097/00004836-200608000-00015 被引量: 178 ...
Liver disease is a high incidence disease in Asia [2,3,4]. There is strong evidence that a sedentary lifestyle and unhealthy dietary habits (especially those with high fat and high salt) are setting the stage for the prevalence of obesity and nonalcoholic fatty liver disease (NAFLD) in ...
Several risk factors are able to predict non-alcoholic fatty liver (NAFL) development, but the predictive value of serum alkaline phosphatase (ALP) remains uncertain. Our aim is to investigate the association between serum ALP levels and NAFL. 21,331 NAFL-free subjects were included. Sex-...
1. Introduction Acute fatty liver of pregnancy (AFLP) is a rare and potentially fatal condition characterized by microvesicular steatosis and liver failure. The pathophysiology remains unclear, but research has implicated defective mitochondrial fatty acid oxidation as a contributing factor. AFLP typically...
ACNAT1 is mainly expressed in the liver and the kidney and efficiently conjugates very long-chain and long-chain saturated fatty acids (C12C24CoA) to taurine (Km=11 μM and Vmax 160 nmol/min/mg for N-palmitoyl taurine production). ACNAT1 catalyzes the conjugation of fatty acids to ...
We also collected data on liver and renal function tests including alanine aminotransferase (ALT), alkaline phosphatase (ALP), glutamyltransferase (GGT), total protein (TP), albumin (ALB), urea, uric acid, creatinine was also measured. Diagnosis of MS and NAFLD The study endpoint was the ...
(AST, ALT) may be normal or elevated and not necessarily related to the severity of the liver disease. Other liver tests such as alkaline phosphatase and bilirubin are often normal. Serum ferritin (a measure of iron storage) may be abnormal. In patients with NAFLD and NASH,cholesterollevels...
Of note, elevated serum liver enzyme activities [e.g. gamma-glutamyltransferase (γGT), alanine aminotransferase (ALT) and alkaline phosphatase)] may independently predict CVD morbidity and/or mortality as well as all-cause death [86], [87], [88], [89]. NAFLD has been associated with ...
Currently, liver tissue biopsy is considered the gold standard for diagnosing MAFLD. However, its clinical use is limited due to its invasive nature.Citation8Magnetic resonance imaging (MRI) and computed tomography (CT) are expensive non-invasive diagnostic methods, while the MAFLD Fibrosis Score and...
Figure 4. Association Between Weight Loss Intervention (WLI) and NAS (Nonalcoholic Fatty Liver Disease Activity Score) View LargeDownload The NAS range is 0-8, with the highest score indicating more severe disease. LF indicates low-fat diet group; MF, moderate-fat diet group. Table. Characteri...