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Nannochloropsis oculata CS179, a unicellular marine microalga, is rich in long-chain polyunsaturated fatty acids (LCPUFAs). Elongase and desaturase play a key role in the biosynthesis of PUFAs. A new elongase gene, which encodes 322 amino acids, was identified via RT-PCR and 5' and 3' ...
A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). In addition, heparan sulfate (HS)-containing PGs in liver have a major physiological function in the retention and internalization of ...
Furthermore, cows fed CS diet exhibited higher ruminal pH, NH3-N and acetate concentration compared to those fed WS diet. Fatty acid supplementation did not alter serum glucose and urea concentration, but increased the serum cholesterol concentration. Although FA supplementation increased net energy ...
Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs are...
thus serving as important intermediaries between tumour cells and the microenvironment. Indeed, in pancreatic ductal adenocarcinomas (PDAC), pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) display elevated synthesis of LPCs from glucose and glutamine, and ultimately release these...
Loomba R, Lawitz E, Mantry PS, Jayakumar S, Caldwell SH, Arnold H, Diehl AM, Djedjos CS, Han L, Myers RP, Subramanian GM, McHutchison JG, Goodman ZD, Afdhal NH, Charlton MR, Investigators G.U (2017) The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a ...
HJ Kim,SH Youn,CS Shin 摘要: Lipase-catalyzed synthesis of sorbitol–fatty acid esters was performed in eutectic media with extremely high substrate concentrations. Homogeneous eutectic melts of sorbitol and fatty acids of C6–C16 were prepared using an adjuvant mixture. Enhanced homogeneity of ...
AB Awad,T Herrmann,CS Fink,PJ Horvath 摘要: Studies have shown that trans fatty acids may play a role in the development of chronic diseases such as heart disease and cancer. The objective of the present project was to examine the effect of supplementation with 18:1 isomers, both ...
Body mass index (BMI) and lipid parameters are the most commonly used anthropometric parameters and biomarkers for assessing nonalcoholic fatty liver disease (NAFLD) risk. This study aimed to assess and quantify the mediating role of traditional and non-traditional lipid parameters on the association...