Most of the remaining patients are compound heterozygotes for the 985A > G allele in combination with 1 of several rarer mutations. Thus, only a few percent of MCAD patients do not have at least one 985A > G allele. The unusually high frequency of a single common mutation has made ...
Further investigation of TUV-2460 in patients with solid tumors could be promising[197]. A novel FAS inhibitor Triazolone GSK2194069 was identified by high throughput screening of GlaxoSmithKline (GSK) compound collection in an assay that measures NADPH consumption using full-length recombinant human ...
it ranged between 1.97 ± 0.26% in arabinose and 6.75 ± 0.34% in sorbitol, while at 45 °C, the lipid content ranged between 1.34 ± 0.35% in sorbitol and 3.42 ± 0.54% in xylose. Productivity of lipids at both temperatures was higher in sorbitol, galactose and...
1. The process of stabilizing against rancidity due to oxidation, fatty materials which are substantially dry and substantially free from organic matter subject to bacterial decomposition, which comprises incorporating therewith a small quantity of a compound selected from the group consisting of ...
Isolation and purification of a 316 Da preformed compound from strawberry (Fragaria ananassa) leaves active against plant pathogens. FEBS letters 459(1), 115–118 (1999). Article CAS PubMed Google Scholar Filippone, M. P., Diaz Ricci, J. Mamanı́ de Marchese, A., Castagnaro, A. &...
Fatty acid methyl ester (FAMEs) standards purchased from Nu-Chek-Prep, INC (Elysian, MN, USA) included GLC744, GLC463, trans fatty acids mixture of GLC 481B with certified quantities of each compound, and an individual triglyceride standard of 1,2,3-triheneicosanoyl-glycerol (TG21:0). ...
CompoundTherapeutic benefits and side effectsMetabolic effectsClinicalTrial.gov ID Obeticholic acid (OCA) (agonist) Improved fibrosis Weight loss NCT02548351 Phase 3 (REGENERATE) HDL decrease, LDL increase AST/ALT levels improvement Pruritus MET409 (agonist) Hepatic fat content reduction Weight loss ...
;SOLUTION: This compound is represented by formula (I) [wherein Ar represents phenyl group or thienyl group substituted with a halogen atom, a 1-6C alkyl group or a 1-6C alkoxy group; R<Sup>1</Sup> represents a halogen atom, a 1-6C alkyl group, a 1-6C alkoxy group, hydroxy group...
Among all the tested conjugates, 5′-O-suberate derivative of AZT (EC50=0.10nM) was found to be the most potent compound and showed 80-fold higher anti-HIV activity than AZT without any significant toxicity (TC50 >500nM).doi:10.1016/j.tetlet.2014.02.001Pemmaraju, Bhanu...
(Fig. 5) dose-dependently inhibited 2-AG hydrolysis by ABHD6 with an IC50of 2.4 μM and had a slightly weaker inhibition potency against FAAH (IC50= 4.0 μM), but no effect on 2-AG hydrolysis by MAGL [51]. Besides, compound2(IC50= 0.8 μM) (Table 2,Fig. 5) showed higher ...