L-FABP protein expression, not detected in control or CP-treated mice, was significantly increased in the proximal tubules of fibrate-treated mice of either group. In the transgenic mice, CP increased the shedding of h-L-FABP in the urine, which was decreased by fibrate as was the acute ...
tubular atrophy and dilatation; ##, hyaline protein casts in tubular lumen; §, pressure-induced deformation of glomerulus; §§, dilatation of Bowman’
Regarding renal function, serum creatinine increased in the ZDF animals compared to the ZL rats, whereas it decreased in the diabetic groups treated with metformin alone or in combination with the CC-supplemented diet (Table 2). Urine glucose decreased in metformin-treated animals compared to all ...