component ‘loads’ acetyl-CoA and malonyl-CoA onto the FAS complex, resulting in the formation of thioester-enzymeintermediates; acyl carrier protein translocates the various thioester intermediates among the catalytic sites of β-ketoacyl reductase, β-hydroxylacyl dehydratase and enoyl reductase. Thioe...
of fatty acid and gene annotation of this locus, five major candidate genes, encoding fatty acid reductase (OsFAR2,Os03g07140), glycerol 3-phosphate acyltransferase (OsGPAT6,Os03g07060), cytochrome oxidase (OsCYP704B2,Os03g07250), and 3-ketoacyl-CoA synthase (OsKCS11,Os03g06700andOs03g0...
General biosynthesis pathway of flavonoids in tea plants. PAL, phenylalanine ammonia lyase; C4H, trans-cinnamate 4-monooxygenase; 4CL, 4-coumarate-CoA ligase; CHS, chalcone synthase; CHI, chalcone-flavanone isomerase; F3H, flavanone 3-hydroxylase; FLS, flavonol synthase; ANR, anthocyanidin reductas...
S1E). However, the transcript levels of HMG-CoA reductase (Fig. 1F), a rate-limiting enzyme for cholesterol synthesis were reduced in LRP1(-/-) cells, whereas LDLr protein levels were increased at day 10 (Fig. 1G), indicating that increased cholesterol storage in the absence of LRP1 is...
SREBP2 transcriptionally controls 3-hydroxy-3-methyglutaryl-coenzyme A (HMG-CoA) reductase, which is a key enzyme in cholesterol synthesis and ketogenesis that closely links to the development of NAFL/NASH.111,112Statins (HMG-CoA reductase inhibitors) restrict cholesterol synthesis and are mostly use...
pre-eclampsia; fatty acid oxidation; long-chain 3-hydroxyacyl-CoA dehydrogenase LCHAD; medium-chain acyl-CoA dehydrogenase MCAD; carnitine palmitoyltransferase CPT; gene expression; qPCR; lipidomic; placental villous explants; placental function1. Introduction 1.1. Etiopathogenesis of Pre-Eclampsia Pre-...
They inhibit HMG-CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase, an enzyme involved in the synthesis of cholesterol in cells [198]. Inhibition of HMG-CoA increases the expression of LDL receptors on the cell surface, causing increased uptake of LDL by cells and consequently reducing ...