Transcripts changing in abundance were enriched in glucose, lipid, and energy-related metabolism, as well as oxo-reductase and cytochrome p450 activities (Fig. 2i, Supplementary Table 1)37. The transcripts with altered splicing patterns were enriched in mRNA processing, signal transduction, and ...
It is possible that its function in transport involves, in addition to acyl-CoA synthase activity, interaction with other membrane proteins. For example, there may be association between FATP4 in enterocytes and other membrane proteins implicated in facilitating FA uptake (see Fig. 66-1). In ...
Complex membrane lipids are also an input source for the intracellular fatty acid pool. Membranes are not a static cellular structure but constantly undergo remodeling via the removal of fatty acids and the addition of fatty acyl-CoAs to glycerophospholipids via the competing actions of phospholipase...
lipid, and energy-related metabolism, as well as oxo-reductase and cytochrome p450 activities (Fig.2i, Supplementary Table1)37. The transcripts with altered splicing patterns were
1) [196]. Malonyl-CoA is the source of the additional carbons which is added to long-chain fatty acyl-CoAs by a series of reactions catalyzed by the elongation of very long-chain fatty acid enzymes (ELOVL1–7), 3-ketoacyl-CoA reductase (KAR; also known as 17β-hydroxysteroid ...
Malonyl-CoA is the source of the additional carbons which is added to long-chain fatty acyl-CoAs by a series of reactions cata- lyzed by the elongation of very long-chain fatty acid en- zymes (ELOVL1–7), 3-ketoacyl-CoA reductase (KAR; also known as 17β-hydroxysteroid dehydrogenase ...
OLE1-1/OLE1-2, ∆9-desaturase; FAD12, ∆12-desaturase; FAD15, ∆15-desaturase; SCD3, stearoyl-CoA desaturase from M. musculus; DGA1, diacylglycerol-acyltransferase; LRO1, phospholipid:diacylglycerol-acyltransferase; ARE1, acyl-CoA:sterol-acyltransferase; POX1, fatty-acyl coenzyme A ...
Each of these FA elongation systems functioning in plastids involves a cycle of four reactions that are catalyzed by the following enzymes: β-ketoacyl- CoA-synthase (KCS), β-ketoacyl-CoA-reductase (KCR), β-hydroxyacyl-CoA-dehydratase (HCD) and trans-2,3-enoyl-CoA-reductase (ECR). It ...
The intracellular fatty acid pool is the source of building blocks for complex lipids and mitochondrial oxidative metabolism (Fig.1; see the “Outputs of the intracellular fatty acyl-CoA pool and their influence on cancer cell behavior” section). This pool has many intracellular and extracellular ...