If the interaction of spectrin with the bilayer is disrupted by treatment with mild oxidizing agents (16) or by disease (44), a looser lipid packing of the outer leaflet results from the introductio...Williams, J. H., Kuchmak, M., and Witter, R. F. (1966) Fatty acids in ...
In large unilamellar vesicles (diameter, similar to 100 nm), the same fatty acids exhibited fast flip-flop but with a measureable rate (t(1/2) = 23 +/- 12 ms). The calculated pseudounimolecular rate constant of the un-ionized FA (k(FAH)) similar to 15 S-1. There was no ...
Transport of unesterified fatty acids (FA) into cells has been viewed either as a simple diffusion process regulated mainly by lipid physical chemistry or as a more complex process involving protein catalysis. In this review FA transport in cell membranes is broken down into three essential steps...
which consists of the fatty acids, is neutral; it is hydrophobic and water-insoluble but is fat-soluble. This amphipathic nature (containing both hydrophobic and hydrophilic groups) makes phospholipids important in membranes; they form a two-layer structure, called thelipidbilayer, with the polar ...
www.nature.com/scientificreports OPEN received: 16 September 2015 accepted: 01 December 2015 Published: 22 January 2016 Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors Ramon Guixà-González1,*, Matti Javanainen2,*, Maricel ...
Lipid - Mobilization, Fatty Acids, Metabolism: In times of stress when the body requires energy, fatty acids are released from adipose cells and mobilized for use. The process begins when levels of glucagon and adrenaline in the blood increase and these
Presents evidence suggesting that membrane proteins may mediate the transport of physiologic fatty acids (FA) across cell membranes. Fluorescence instrumentation; Determination of vesicle lamellarity; Partition coefficients; Rate constants for FA dissociating from, transferring across and binding to lipid vesi...
Interestingly, both, the APP and all APP secretases are transmembrane proteins which cleave APP close to and in the lipid bilayer. Moreover, apolipoprotein E4 (apoE4) has been identified as the most prevalent genetic risk factor for AD. ApoE is the main lipoprotein in the brain, which has...
Lipid - Waxes, Fatty Acids, Esters: A second group of neutral lipids that are of physiological importance, though they are a minor component of biological systems, are waxes. Essentially, waxes consist of a long-chain fatty acid linked through an ester o
An alternative technique for detecting lipid peroxidation utilizes the oxidation-induced decrease of concentration-dependent excimer formation by BODIPY FL dye–labeled fatty acids. Figure 13.2.1 Location and orientation of representative fluorescent membrane probes in ...