This simple hypothesis was later challenged by the discovery of several proteins that appeared to be membrane-related fatty acid transporters. In addition, some biophysical studies suggested that fatty acids moved slowly through the simple model membranes (phospholipid bilayers), which would provide a ...
This question will be addressed by dissecting transport into each of its steps, understanding the physical chemical principles derived from simple model systems, and assessing the relevancy of such information to cell membranes. ADSORPTION The first step in the transport of FA across a membrane, ...
In addition, siRNA knockdown of fatty acid transport protein-1 (FATP-1) or fatty acid translocase (FAT/CD36) significantly decreased [1-14C]oleate incorporation into the basolateral media. In summary, transport of oleate across HBMECs is, in part, a transcellular process. Oleate transport ...
Recently, fatty acid transport across the plasma membrane has been shown to be a key process that contributes to the regulation of fatty acid metabolism in... A Chabowski,I Momken,SLM Coort,... - 《Molecular & Cellular Biochemistry》 被引量: 261发表: 2006年 Role of short-chain fatty ac...
We conclude that long chain fatty acid transport in adipocytes is very likely mediated by an as-yet-unidentified membrane protein pump. 展开 关键词: Animals Mice 3T3-L1 Cells Cell Membrane Cholesterol Adenosine Triphosphate Fatty Acids, Nonesterified Recombinant Proteins Antigens, CD36 Microscopy, ...
Presents evidence suggesting that membrane proteins may mediate the transport of physiologic fatty acids (FA) across cell membranes. Fluorescence instrumentation; Determination of vesicle lamellarity; Partition coefficients; Rate constants for FA dissociating from, transferring across and binding to lipid vesi...
Evidence shows that fatty acids are actively transported across cell membrane by specialized proteins instead of by passive diffusion11. In the liver, the major proteins involved in fatty acid transport and trafficking included the fatty acid transport proteins, FATP2 (SLC27A2) and FATP5 (SLC27...
The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids (PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the phospholipid cell membrane. Once PUFAs are released from the membrane, they can participate in signal transduction, either...
As revealed by scanning pH-sensitive microelectrodes, the pH shift occurred only in the immediate vicinity of the membrane, while bulk pH remained unchanged. In concurrence with the theoretical model of weak acid transport, the pH value at maximum proton flux was almost equal to the pK of the...
Fatty acid use is a critical source of bioenergy for the adult heart. Fatty acid transport into the cardiomyocytes and within the cell is a highly regulated process involving specific transport proteins located in the plasma membrane, fatty acid–binding proteins, and transporters within the mitochond...