The role of lipid metabolism in human pluripotent stem cells (hPSCs) is poorly understood. We have used large-scale targeted proteomics to demonstrate that undifferentiated hPSCs express different fatty acid (FA) biosynthesis-related enzymes, including ATP citrate lyase and FA synthase (FASN), than ...
Here, we show that fatty acid (FA) synthesis activation is critical for stem cell pluripotency. Our initial observations demonstrated enhanced lipogenesis in pluripotent cells and during cellular reprogramming. Further analysis indicated that de novo FA synthesis controls cellular reprogramming and embryonic...
Fatty acid synthase (FASN) is a multienzyme protein that catalyzes the synthesis of fatty acids (mainly the long-chain saturated fatty acid palmitate) from acetyl-CoA and malonyl-CoA in the presence of nicotinamide adenine dinucleotide phosphate reduced form (NADPH)1. Most adult tissues satisfy the...
in cancer cells, blockingmonounsaturated fatty acidssynthesis by inhibiting stearoyl-CoA-desaturase 1 (SCD1) reduced YAP/TAZ stabilization and nuclear localization (Noto et al., 2017), indicatingfatty acid synthesismay also contribute to the hyperglycolytic phenotype of endothelium exposed to disturbed ...
Cancer cells need to adapt their metabolic state to different microenvironments, particularly during metastatic spread, when they are exposed to the circulatory system as well as the distant organ. Two studies now show that upregulation of fatty acid synthesis is required for the formation of breast...
demonstrated that miR-140 was an upstream regulator ofTGFA, and miR-140 could inhibit (P<0.01) unsaturated fatty acid and triglyceride (TAGs) production in bovine mammary epithelial cells (BMECs). In contrast,TGFApromoted (P<0.01) unsaturated fatty acid and TAG production. Rescue experiments ...
coli. Especially, we will sum up possibilities to genetically modify this bacterium towards an overproduction of fatty acids or fatty acid-derived biofuels. Fatty acid biosynthesis Synthesis of fatty acids is one of the most ubiquitous pathways in organisms. In eukaryotic and prokaryotic cells fatty ...
FATTY ACID SYNTHESIS IN NORMAL AND COLD-ACCLIMATED RATS. Can J Physiol Pharmacol. 1964 Jan;42:101-7. JK Patkin,EJ Masoro - 《Can J Physiol Pharmacol》 被引量: 31发表: 1964年 加载更多来源期刊 Febs Letters 研究点推荐 Fatty acid synthesis white adipose tissue brown adipose tissue 引用走势...
Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear. Here, we show that surplus fatty acid synthesis in adipocytes induces necroptos
As expected, MOD1, a key enzyme of fatty acid synthesis, was found as a chloroplast-localized protein (Figure 2H and Supplementary information, Figure S1). The distinctive subcellular localization patterns of SOM3 and MOD1 suggest that the cell death modulated by these two proteins involves an ...