1)fatty acid oxidation disorders线粒体脂肪酸氧化功能障碍 2)mitochondrial dysfunction线粒体功能障碍 1.Objective:To study the effect of mitochondrial dysfunction on hippocampal cell apoptosis in kainite acid-induced epilepsy in rat.目的:观察海人酸(KA)颞叶癫痫大鼠海马细胞内游离钙离子浓度、线粒体膜电位及...
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Described herein is the use of PPARδ agonists in the treatment of fatty acid oxidation disorders. C O'Carroll,N O'Donnell,L Purkins,... 被引量: 0发表: 2022年 Mitochondrial Fatty Acid Oxidation Disorders Mitochondrial fatty acid oxidation disorders (FAODs) impair the ability of the body to...
摘要: Fatty acid oxidation disorders often present with intermittent symptoms triggered by prolonged fasting. Avoidance of fasting is a key component of treatment. Symptoms of cardiac or skeletal muscle dysfunction pose problems, particularly for patients with long-chain fatty acid oxidation disorders....
A subsequent small trial (6 patients) indicated improvement over a 3 year period of treatment [237]. Expansion of this therapy to other long chain fatty acid oxidation disorders may be possible. Use of triheptanoin, a novel odd, medium chain triglyceride has been reported to be of ...
必应词典为您提供fatty-acid-oxidation-disorders的释义,网络释义: 线粒体脂肪酸氧化功能障碍;脂肪酸氧化代谢病;
Experience with new-born screening (NBS) for disorders of fatty-acid oxidation (FAOD) is now becoming available from an increasing number of programs worldwide. The spectrum of FAOD differs widely between ethnic groups. Incidence calculations from reports from Australia, Germany, and the USA of a...
In fatty acid oxidation disorders, with increased glucose demands during fasting (because alternative fuels are not available), glucose production does not keep pace with glucose demand, and hypoglycemia ensues[112]. When ketone production is low (e.g., absent urine ketones, normal βHB) and FFA...
(e−) are passed to the respiratory chain either directly or via transfer proteins (ETF, ETF-QO). Acetyl-CoA can be oxidised in the tricarboxylic acid (Krebs) cycle or, in the liver, used to synthetize ketone bodies. Fatty acid oxidation disorders mentioned in this manuscript are labelled...
Fatty acid oxidation disorders (FAODs) are potentially fatal inherited disorders for which management focuses on early disease detection and dietary intervention to reduce the impact of metabolic crises and associated spectrum of clinical symptoms. They can be divided functionally into long-chain (LC-FA...