The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk
Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor essential for cancer cell survival. The reprogramming of lipid metabolism has emerged as a hallmark of cancer, yet the relevance of HIF-1α to this process remains elusive. In this stud
Analytical and clinical evaluation of a new heart-type fatty acid-binding protein automated assay. Clin Chem Lab Med 2006;44(11):1383-5.Analytical and clinical evaluation of a new heart-type fatty acid-binding protein automated assay[J] . Martina Zaninotto,Monica Maria Mion,Enrica Novello,...
Mechanistically, B. coccoides stimulated mucus growth through the production of the short-chain fatty acids propionate and acetate via activation of the short-chain fatty acid receptor Ffar2, which could serve as a new target to restore mucus growth during mucus-associated lifestyle diseases....
Regulation of fatty acid metabolism by SCFAs SCFAs regulate the balance between fatty acid synthesis, fatty acid oxidation, and lipolysis in the body. Fatty acid oxidation is activated by SCFAs, while de novo synthesis and lipolysis are inhibited. The net result is a reduction of the concentration...
ACC, acetyl-CoA carboxylase; Elovl, fatty acid elongase; FA, fatty acid; INS, rat insulinoma; MUFA, monounsaturated fatty acid; SCD, stearoyl-CoA desaturase. Selective knockdown of Elovl-5 or Elovl-6 alters synthesis of specific MUFA species siRNAs were used to determine the relative ...
Nonalcoholic steatohepatitis (NASH) can progress into liver cirrhosis; however, no definite treatment is available. Omega-3 polyunsaturated fatty acid (omega-3) has been reported to alleviate experimental NASH, although its beneficial effect was not evid
In addition, we sought to describe fatty acid intake in relation to the diet as a whole. Thus, the intake of n-6 and n-3 fatty acids were compared to the intake of other nutrients and to the calculated Healthy Eating Index (HEI) scores, which are a measure of the overall health...
Among the most prominent metabolic alterations in cancer cells are the increase in glucose consumption and the conversion of glucose to lactic acid via the reduction of pyruvate even in the presence of oxygen. This phenomenon, known as aerobic glycolysis or the Warburg effect, may provide a ration...
Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during a