Microsomal fractions from rat small intestine contain a fatty-acid chain-elongation activity. Cofactor requirements are similar to those of the liver microsomal system, but substrate specificity is different. The polyunsaturated arachidonic and timnodonic acids were elongated at very low rates. These res...
Recently, the fatty acid elongation enzyme ELOVL5 was identified as a critical pro-metastatic factor in prostate cancer, required for cell growth and mitochondrial homeostasis. The fatty acid elongation reaction catalyzed by ELOVL5 utilizes malonyl-CoA as the carbon donor. Here, we demonstrate that ...
The biosynthesis of ‘unusual’ fatty acids with structures that deviate from the common C16 and C18 fatty acids has evolved numerous times in the plant kingdom. Characterization of unusual fatty acid biosynthesis has enabled increased understanding of e
We observed that the presence of microbes increases desaturation of palmitate (FA 16:0n-7) by SCD1 and elongation of γ-linoleic acid (FA 18:3n-6) to dihomo-γ-linolenic acid (FA 20:3n-6) by ELOVL5. Interestingly, SCD1 activity has been linked to various diseases including diabetes, ...
ECERIFERUM2-LIKE Proteins Have Unique Biochemical and Physiological Functions in Very-Long-Chain Fatty Acid Elongation1[OPEN] ECERIFERUM2-LIKE Proteins Have Unique Biochemical and Physiological Functions in Very-Long-Chain Fatty Acid Elongation1[OPEN]Figure 1. Expression of CER2-... TM Haslam,R ...
Acetyl-CoA carboxylase (ACCase) catalyses the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. In Arabidopsis thaliana, ACC1 and ACC2, two genes ...
Here, we report that the R2R3-type MYB96 transcription factor regulates fatty acid elongation in seeds by directly modulating expression of FAE1, an well-known seed-specific β-ketoacyl–CoA synthase (KCS) that catalyzes the first condensation reaction in VLCFA elongation. The FAE1 gene was up...
A fatty acid elongation defective mutant was isolated from Saccharomyces cerevisiae by mutagenizing strains that were defective in fatty acid synthase (FAS... DA Toke - Rutgers The State University of New Jersey - New Brunswick. 被引量: 0发表: 1996年 Mutants of Arabidopsis with Alterations in ...
Fatty acid elongation in yeast : Biochemical characteristics of the enzyme system and isolation of elongation-defective mutants Elongation of long-chain fatty acids was investigated in yeast mutants lacking endogenous de novo fatty acid synthesis. In this background, in vitro fatty ... F Dittrich,D...
Fatty acid elongation in developing seeds of Arabidopsis thaliana Six mutants of Arabidopsis thaliana (L.) Heynh., with reduced levels of very long chain fatty acids (VLCFAs) in their seed lipids, were isolated by direct ... L Kunst,D Taylor,EW Underhill - 《Plant Physiology & Biochemistry...