The prototypical type II fatty acid synthesis (FAS) pathway in bacteria utilizes two distinct classes of β-ketoacyl synthase (KAS) domains to assemble long-chain fatty acids, the KASIII domain for initiation and the KASI/II domain for elongation. The central role of FAS in bacterial viability...
Townsend, The potential role of fatty acid initia- tion in the biosynthesis of the fungal aromatic polyketide a£atoxin B-1, Can. J. Chem. Rev. Can. Chim. 72 (1994) 200^207.Brobst SW, Townsend CA. 1994. The potential role of fatty acid initiation in the biosynthesis of the fungal...
The genes fabH, fabD and fabG encode for proteins that catalyze subsequent steps in the initiation of fatty acid biosynthesis. They are transcribed by a strong promoter within the upstream region of plsX and a weak promoter upstream of fabD[64, 160]. The strong promoter has been investigated ...
Fatty acid synthesis in green organisms takes place in the plastid and is initiated by conversion of acetyl-CoA to malonyl-CoA by acetyl-CoA carboxylase (ACCase) [66], a highly regulated enzyme and therefore essential in controlling the initiation of fatty acid biosynthesis [67]. Subsequently, ...
The genes fabH, fabD and fabG encode for proteins that catalyze subsequent steps in the initiation of fatty acid biosynthesis. They are transcribed by a strong promoter within the upstream region of plsX and a weak promoter upstream of fabD[64, 160]. The strong promoter has been investigated ...
The type II fatty acid biosynthesis (FAB) pathway is recognized as the primary route of fatty acid production byE. coli[35]. Figure1briefly illustrates the anabolic and catabolic metabolism of octanoic acid (C8) withinE. coli. Acetyl-CoA serves as both initiation primer of fatty acid synthesis...
Initiation of fatty acid biosynthesis in Pseudomonas putida KT2440 2023, Metabolic Engineering Citation Excerpt : Heterologous expression of madB in the ΔEcfabH mutant restored wild type-like growth, comparable to the EcfabH control (Fig. 3C and Fig. S5). In addition to a small colony phenotyp...
coli fabH in Xcc EcH could increase the rate of fatty acid biosynthesis to support growth of the mutant. However, there are other possible causes for the weak growth of the fabH mutant, and these possibilities are being further investigated. Replacement of Xcc fabH with E. coli fabH ...
1331 Figure 1 Schematic diagram of fatty acid biosynthesis process. The catalytic process is divided into initiation and elongation stages. In the initiation stage, apo-form of acyl carrier protein (apo-ACP, green) is covalently installed with a 4′-phosphop- antetheine moiety (4′-Pan-arm) ...
Although fatty acid (FA) biosynthesis pathway genes have been all cloned and biosynthesis pathway was built up in some higher plants, the molecular mechanism for its regulation in microalgae is far away from elucidation. Results We cloned main key genes for FA biosynthesis in Haematococcus pluvialis...