We develop soft and stretchable fatigue-resistant hydrogel optical fibers that enable optogenetic modulation of peripheral nerves in naturally behaving animals during persistent locomotion. The formation of polymeric nanocrystalline domains within the hydrogels yields fibers with low optical losses of 1.07 ...
Flexible and fatigue-resistant optical fibers made from hydrogel allow optogenetic manipulations in the periphery in freely behaving mice.doi:10.1038/s41592-023-02020-9Liu XinyueMassachusetts Institute of TechnologyRao SiyuanResearch Laboratory of ElectronicsChen WeixuanFelix KaylaNi JiahuaSahasrabudhe Atharv...
a,bA glass optical fiber (200 μm in diameter) with (b) and without (a) fatigue-resistant hydrogel coatings. Inset inbconfocal laser-scanning microscopic (CLSM) image of the hydrogel coating (∽20 μm in thickness) on the glass optical fiber.c,dA glass tube with (d) and without ...