Definitions and measures of fatigue in long COVID cover different dimensions, such as physical, cognitive, emotional, psychosocial, and general fatigue and post exertional malaise (Thomas et al., 2024 [Unpublished raw data]). It is unclear if different dimensions share the same underlying ...
Viral meningitis may be preceded for several days by a non-specific flu-like illness consisting of low-grade fever, sore throat, malaise, anorexia, nausea, vomiting, diarrhea, headache, and photophobia. Specific non-neurologic syndromes, such as rashes, pleurodynia, or pericarditis (se...
Felger JC, Miller AH (2012) Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol 33(3):315–27. doi:10.1016/j.yfrne.2012.09.003 Article PubMed Central CAS PubMed Google Scholar Raison CL, Dantzer R, Kelley KW,...
lasting 6 months or more, impairment of neurocognitive functions and quality of sleep, and of somatic symptoms, such as recurrent sore throat, muscle aches, arthralgias, headache and postexe
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized that a significant portion of the affected individuals developed long-term debilitating symptoms marked by chronic fatigue, cognitive difficulties (“brain fog”), post-exertional malaise, and autonomic dysfunctio...
under resting or post-exercise conditions[87]. When recombinant IL-6 is actively administered, it impairs the performance of long-distance runners and increases the sensation of fatigue in trained runners[84]. Fatigue resistance was also found to be worse in patients with high levels of IL-6 ...
energetic situation. This, in turn, should again favor compensatory release and spillover of inflammatory vasodilators including PGE2to further stimulate thermogenesis resulting in a potential vicious (“pyretic”) cycle (Fig.4). Energy depletion could finally cause hypothermia. Would sensation of cold...
It is widely believed that pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 are responsible for triggering sickness behaviour, which includes symptoms such as malaise, fever, loss of appetite, decreased libido, depressed mood, lethargy, pain hypersensitivity, excessive sleepiness, ...
Early indications of vitamin C deficiency may be manifested as fatigue, malaise, and a reduced desire to be physically active [79]. The results of the study suggested that the fatigue scores decreased significantly in the vitamin C group after two hours and remained lower for one day. It ...
(IPF) and sarcoidosis. More than 50% of the patients with IPF reported fatigue as being one of their most significant symptoms, which can manifest in a variety of ways, such as physical fatigue, including muscle fatigue, persistent lack of energy, and overall malaise [7]. The prevalence of...