lasting 6 months or more, impairment of neurocognitive functions and quality of sleep, and of somatic symptoms, such as recurrent sore throat, muscle aches, arthralgias, headache and postexe
Felger JC, Miller AH (2012) Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol 33(3):315–27. doi:10.1016/j.yfrne.2012.09.003 Article PubMed Central CAS PubMed Google Scholar Raison CL, Dantzer R, Kelley KW,...
• Accompanied by any of the following specified new symptomsc including post-exertion malaise,i impaired memory or concentration, unrefreshing sleep, sore throat, tender cervical or axillary lymph nodes, muscle pain, multi-joint pain, or new headaches.j Level 1c (other fatigue syndrome) •...
Would sensation of cold, similar to environmental cold—cold stress—then also raise sympathetic tone to cause (more) vasoconstriction and potentially (further) stimulate thermogenesis as illustrated in Fig. 4? Such a vicious cycle could be of relevance in particular for severe ME/CFS where it ...
energetic situation. This, in turn, should again favor compensatory release and spillover of inflammatory vasodilators including PGE2to further stimulate thermogenesis resulting in a potential vicious (“pyretic”) cycle (Fig.4). Energy depletion could finally cause hypothermia. Would sensation of cold...
under resting or post-exercise conditions[87]. When recombinant IL-6 is actively administered, it impairs the performance of long-distance runners and increases the sensation of fatigue in trained runners[84]. Fatigue resistance was also found to be worse in patients with high levels of IL-6 ...
under resting or post-exercise conditions[87]. When recombinant IL-6 is actively administered, it impairs the performance of long-distance runners and increases the sensation of fatigue in trained runners[84]. Fatigue resistance was also found to be worse in patients with high levels of IL-6 ...
(IPF) and sarcoidosis. More than 50% of the patients with IPF reported fatigue as being one of their most significant symptoms, which can manifest in a variety of ways, such as physical fatigue, including muscle fatigue, persistent lack of energy, and overall malaise [7]. The prevalence of...
Fatigue is amongst common complaints in daily life, negatively impacting work performance, family life, and social relationships. Fatigue can be conceptualised as a sensation of exhaustion or difficulty performing intellectual or physical activities, which is often not recovered after a period of rest ...
“politics in general” probably did not refer to issue fatigue, but rather to a more general political malaise (for an overview, see Maurer 2003; Wolling 1999); fifthly, topics should be politically, economically, and/or socially relevant; as such, we excluded mentions of non-political or...