RA and healthy synoviocytes were used as controls. To measure cell proliferation/ ...doi:10.1186/ar3566Serena GuiducciEloisa RomanoClaudia Ceccarelli…BioMed CentralArthritis Research & Therapy
In addition, anti-fasL antibody therapy reduced murine GVHD in a manner complementary to anti-TNF-α antibody [153]. FasL appears to be relevant in clinical GVHD, as subjects with acute GVDH [154,155] and chronic GVHD [156] have increased serum levels of soluble fasL. View article Chapter...
Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer Tanmoy Mondal, Himanshu Gaur, Brice E. N. Wamba, Abby Grace Michalak, Camryn Stout, Matthew R. Watson, Sophia L. Aleixo, Arjun Singh, Salvatore Co...
Since defective FAS signaling may render the T-LBL tumor cells resistant to apoptotic cell death, the correct prognosis, diagnosis and thus the success of anticancer therapy may require such an in-depth knowledge of the complete scenario of FAS-signaling alterations. Cell Death and Disease (2014)...
Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia Blood, 78 (1991), p. 1198 View PDFView articleView in ScopusGoogle Scholar 18 Iwai K, Miyawaki T, Takizawa T, Konno A, Ohta K, Yachie A, Seki H, Taniguchi N Differential expression of bcl-2 ...
Although low-dose cytosine arabinoside (LD-Ara-C) therapy has been accepted as an effective treatment for patients with acute non-lymphocytic leukemia (ANLL) transformed from myelodysplastic syndromes or elderly patients with ANLL, the anti-leukemic mechanism remains to be resolved. Recently, the pote...
It may be expected that biological removal of the RA synovium will become a new complementary therapy with systemic anti-rheumatic drugs in future. Conclusions ARG098, a novel anti-Fas/APO-1/CD95 monoclonal antibody, exhibits potency for treating RA synovial hyperplasia, which plays crucial roles...
monoclonal antibody MACS: magnetic-activated cell sorting MyD88: myeloid differentiation primary response gene 88 ODN: oligonucleotide PBS: phosphate-buffered saline PO: phosphodiester PS: phosphorothioate SLE: systemic lupus erythematosus TLR: Toll-like receptor TNF: tumor necrosis factor.Refe...
Mouse anti Fas monoclonal antibody (IgM) was prepared in the same manner as mentioned above Yonehara et al. (1989) op. cit.! and purified by column chromatography on hydroxyapatite. (2) Construction of cDNA Library Total RNA (2.7 mg) was prepared from the KT-3 cells (1.2×109), by th...
1.A monoclonal antibody, or fragment thereof, which specifically binds human fatty acid synthase (hFAS) that is not the monoclonal antibody known as M3 or M6. 2.The monoclonal antibody, or fragment thereof, of claim 1 which binds an hFAS polypeptide of about 250 kD and/or a proteolytic ...