产品名称:Farnesoid X receptor/FXR重组蛋白 英文名称:Recombinant Farnesoid X Receptor (FXR) NR1H4; BAR; FXR; HRR1; RIP14; Nuclear Receptor Subfamily 1,Group H,Member 4; Bile acid receptor; Farnesol receptor HRR-1; Retinoid X receptor-interacting protein 14 来源:原核表达 宿主:E.coli ...
网络释义 1. 受体 法尼醇X受体(farnesoid X receptor)的配体可抑制肌纤维母细胞纤维形成作用,和PPARγ 配体合用可能提高疗效。 一些抗氧 … www.docin.com|基于 1 个网页
Farnesoid X receptor (FXR), a nuclear receptor for maintaining bile acid homeostasis, has been recognized as a tumor suppressor in enterohepatic tissues. However, its expression and functional role in non-small cell lung cancer (NSCLC) remain unclear. We report that FXR is significantly increased ...
Farnesoid X Receptor (FXR) BioAssay ELISA Kit (Rat) is a sandwich enzyme immunoassay for in vitro quantitative measurement of FXR in rat tissue homogenates and other biological fluids.Detection Range:0.156-10ng/mlSensitivity:0.061ng/mlStorage and Stabili
Farnesoid_X_receptor抑制剂_激动剂_MCE FXR Farnesoid X receptor encoded by the NR1H4 gene in humans. FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. When activated, FXR translocates to the cell nucleus, forms ...
Farnesoid X Receptor (FXR)Farnesoid X Receptor (FXR)FXR is involved in the regulation of the bile acid metabolism. Chenodeoxycholic acid binds to FXR and subsequently, cholesterol 7伪-hydroxylase is down-regulated and bile acids are transported from the gut to the liver. Chenodeoxycholic acid indir...
Farnesoid x receptor (fxr) functions as a bile acid receptor/sensor that mediates cyp7 expression in a bile-acid dependent manner; drug screening for anticholesterol agentsdoi:US6465258 B1This invention provides methods and compositions that are useful for modulating cholesterol levels in a cell, ...
Introduction: Farnesoid-X-receptor (FXR) is the receptor for primary bile acids expressed in enterohepatic tissues where it regulates bile acid uptake, metabolism and disposal. For its role as a bile acid sensor, FXR has been thought to be an important target in the treatment of cholestatic ...
The farnesoid X receptor (FXR) is a bile sensor that acts in coordination with other nuclear receptors to regulate essential steps in bile acid uptake, metabolism and excretion. In addition, FXR is an ancillary receptor involved in lipid and glucose homeostasis. Steroidal and non-steroidal FXR li...
是一种farnesoid X receptor(FXR)(法尼酯X受体)激动剂,EC50为65 nM。GW 4064是一种完全激动剂,在转染有鼠源和人源FXR表达载体以及确定的报告 基因的CV-1细胞中, EC50分别为80和90。GW 4064直到1 μM浓度对其它核受体也没有活性,包括维甲酸受体。因此, GW 4064是一种强有效和选择性的非类固醇 FXR激动剂。