Farnesoid X receptor (FXR) plays an indispensable role in liver homeostasis and has been a promising drug target for hepatic diseases. However, the concerns of undesired biological actions limit the clinical applications of FXR agonists. To reveal the intrinsic mechanism of FXR agonist-induce ...
BPS Bioscience FXR(Farnesoid X 受体)激动剂检测试剂盒基本参数: 货号:78131 英文名称:FXR Agonist Assay Kit (TR-FRET) 规格:384 rxns. 同义词:Nuclear Receptor Subfamily 1 Group H Member 4 kit, Bile Acid Receptor Assay, RIP14 assay kit, HRR1 assay kit 检测试剂盒格式:TR-FRET 提供方式:384反应格...
Farnesoid X Receptor (FXR) agonist for use in the treatment or prevention of certain cancers, metastases, precancerogenic lesions or angiogenesis in the context of cancer in a patient, wherein the Farnesoid X Receptor (FXR) agonist is administered in a therapeutically effective amount to the ...
S2782GW4064GW4064 is an agonist offarnesoid X receptor (FXR)with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM. GW4064 stimulatesautophagyin MCF-7 cells. Gut Microbes, 2024, 16(1):2379566 ...
The farnesoid X receptor (FXR)/βKlotho/fibroblast growth factors (FGFs) pathway is crucial for maintaining the intestinal barrier and preventing colorectal cancer (CRC). We used an FXR agonist, GW4064, and FXR-knockout (FXR-KO) mice to investigate the role of FXR/Klothos/FGFs pathways in ...
A new class called Farnesoid X receptor (FXR) agonistSearch Main menu Skip to primary content Skip to secondary content Home IP3R2 ABT-263 CAY10683 ISO-1 PF-04418948 SQ22536Rendering Styles of Thoughtful Towns as well as Loving Towns at the End of Existence: A planned out Review. Posted ...
Functional characterization of the semi-synthetic bile acid derivative INT-767, a dual FXR and TGR5 agonist Mol. Pharmacol. (2010) Google Scholar [72] Y.T. Li, K.E. Swales, G.J. Thomas, T.D. Warner, D. Bishop-Bailey Farnesoid x receptor ligands inhibit vascular smooth muscle cell infl...
Farnesoid X receptor (FXR, encoded by NR1H4), a bile acid-activated nuclear receptor, is widely implicated in human tumorigenesis. The FXR agonist obeticholic acid (OCA) has preliminarily displayed tumour suppressor potential. However, the anticancer effects of this agent on colorectal cancer (CRC...
Farnesoid_X_receptor抑制剂_激动剂_MCE FXR Farnesoid X receptor encoded by the NR1H4 gene in humans. FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. When activated, FXR translocates to the cell nucleus, forms ...
The farnesoid X receptor (FXR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR is mainly expressed in liver and small intestine, where it plays an important role in bile acid, lipid, and glucose metabolism. The kidney also has a high FXR expression...