四川省人民医院核医学科关于FAPI-RGD双靶点药物临床转化研究的最新成果“A comparison of Al18F- and68Ga-labeled dual targeting heterodimer FAPI-RGD in malignant tumor: preclinical evaluation and pilot clinical PET/CT imaging”在国际权威的影像学...
在接受68Ga-FAPI-RGD和18F-FDG双示踪剂 PET/CT的患者中,选取17例初始分期的患者进行数据分析,结果显示,68Ga-FAPI-RGD PET/CT在所有原发性肿瘤中检测结果为19/19,而后者漏检3例肿瘤病变和1例多灶性乳腺癌,并且在所有的原发肿瘤中,68Ga-FAPI-RGD PET/CT组的SUVmax值显著高于18F-FDG PET/CT。(中位SUVmax...
因此,患者被诊断为放射性碘难治性分化型甲状腺癌。与 18F-FDG PET/CT 相比,68Ga-FAPI-RGD PET/CT 显示更高的示踪剂摄取和更清晰的病变边界。这表明 177Lu-FAPI-RGD 可能作为放射性碘难治性分化型甲状腺癌的治疗选择。 "点击查看英文标题和摘要"
The average SUVmax of 68Ga-FAPI-RGD PET was significantly higher than that of 18F-FDG PET in 42 primary malignant neoplasms (mean diameter 2.5 ± 1.9 cm) with a statistically significant difference (6.9 ± 5.3 vs. 5.3 ± 5.4, P [1]: pending:yesRongxi Wang...
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Due to the heterogeneity of tumors, strategies to improve the effectiveness of dual-targeting tracers in tumor diagnostics have been intensively practiced. In this study, the radiolabeled [18F]AlF-NOTA-FAPI-RGD (denoted as [18F]AlF-LNC1007), a dual-targeting heterodimer tracer targeting both ...
For metastatic tumors, the SUVmax and TBR from [68Ga]Ga-FAPI-RGD PET/CT were higher than those from [68Ga]Ga-FAPI-02 (SUVmax: 6.30 ± 1.87 vs . 2.02 ± 0.28, P = 0.000; TBR: 5.69 ± 3.39 vs . 1.69 ± 0.67, P = 0.001). Conclusions: [68Ga]Ga-FAPI-RGD is a promising ...