4. Zhao L, Niu B, Fang J, et al. Synthesis, preclinical evaluation, and a pilot clinical PET imaging study of68Ga-labeled FAPI dimer. J Nucl Med. 2022;63:862–868. 5. Zhao L, Chen J, Pang Y, et al. Developme...
DimerTechnetium-99mSPECT imagingFibroblast activation protein (FAP) is a crucial target for tumor diagnosis and treatment. FAP inhibitors (FAPIs) can selectively bind to FAP, and ligands with multiple targeting groups are anticipated to improve tumor-specific uptake. A dimeric FAPI ligand (L2) ...
dimer摄取的病灶比较结果,其中,a为 68 ga ‑ fapi ‑ 46注射1h后的pet显像结果,b为 68 ga ‑ 2peg(3) ‑ fapi ‑ dimer注射1h后的pet显像结果,c为 68 ga ‑ 2peg(3) ‑ fapi ‑ dimer注射4h后的pet显像结果,d为对转移淋巴结进行穿刺的苏木精和伊红(h&e)染色和fap免疫组织化学染色结果...
18. Zhao L, Niu B, Fang J, et al. Synthesis, preclinical evaluation, and a pilot clinical PET imaging study of (68)Ga-labeled FAPI dimer[J]. J Nucl Med, 2021. DOI: 10.2967/jnumed.121.263016. 19. Xu M, Zha...
In recent years, quinoline-based fibroblast activation protein (FAP) inhibitors (FAPIs; e.g., FAPI-04 and FAPI-46) have shown promising results in the diagnosis of cancer and various other diseases, making them the hot spot of much productive research (1). However, one major issue is that...
Chemical structures of the selected FAP tracers for diagnostic use, except (DOTAGA.(SA.FAPi)2, which is the dimer of the diagnostic tracer DOTA.SA.FAPi and more suitable for therapeutic purposes due to the longer tumor retention. Full size image ...
The in vitro binding affinity and preclinical small animal PET imaging of the compounds were compared with their monomeric counterparts, FAPI-04 and FAPI-46. The lead compound, [Ga-68]Ga -LNC1013, was then evaluated in a pilot clinical PET imaging study involving seven patients with ...
dimerradioligand therapyVisual Abstract Radiolabeled fibroblast activation protein (FAP) inhibitors (FAPIs) have shown promise as cancer diagnostic agents; however, the relatively short tumor retention of FAPIs may limit their application in radioligand therapy. In this paper, we report the design, ...
The study aimed to assess the safety and efficacy data of [177Lu]Lu-DOTAGA.FAPi dimer radionuclide therapy in patients with advanced stage MTC. Methods: In this retrospective study from June 2021 to October 2022, 13 MTC patients heavily pretreated (46% refractory to [177Lu]Lu-PRRT, 23% ...
4. Zhao L, Niu B, Fang J, et al. Synthesis, preclinical evaluation, and a pilot clinical PET imaging study of68Ga-labeled FAPI dimer. J Nucl Med. 2022;63:862–868. 5. Zhao L, Chen J, Pang Y, et al. Developme...