实体瘤 TME 中的 FAP CAR-T 细胞 目前clinical.gov上登记有两款FAP CAR-T药物:F19 FAP-CAR-T-cells(NCT01722149)和CAR-T targeting Nectin4/FAP(NCT03932565),适应症分别为恶性胸膜间皮瘤及晚期恶性实体瘤。 2015年记录了局部F19 FAP-CAR-T细胞治疗后的第一个病人报告,没有观察到细胞因子风暴或炎症。 总结...
参考文献：[1] World Health Organization. (2023, July 11). Colorectal cancer. Retrieved May 10, 2024, from https://www.who.int/zh/news-room/fact-sheets/detail/colorectal-cancer[2] Mayo Clinic. (n.d.). Familial adenomatous polyposis. Retrieved May 10, 2024, from https://www.mayoclinic....
Methods: This prospective clinical trial ([NCT05930457][1]) was conducted from July 2023 to December 2023. All patients underwent [18F]F-FDG (60min) and [64Cu]Cu-FAPI-XT117 PET/CT (3 time-point including 30min, 60min, 120min after administration) within four weeks. [18F]F-FDG and ...
2Study of [68Ga]FAPI-46 PET in Patients With Pancreatic Ductal Carcinoma (FAPI-46 PDAC) - Full Text View - ClinicalTrials.gov. (n.d.).https://classic.clinicaltrials.gov/ct2/show/NCT05262855(Accessed: October 4 2023). 3Study of [18F]FAPI-74 PET in Patients ...
结直肠癌(CRC)是全球最常见的恶性肿瘤之一,发病率和死亡率逐年上升,且趋于年轻化。根据WHO的统计,CRC约占所有癌症病例的10%,是全球癌症相关死亡的第二大原因。预计到2040年,CRC的全球负担将增加到每年320万例新发病例和160万例死亡病例[1]。因此,研究CRC的机制并开发相关的治疗方法,成为肿瘤治疗研究的重要任务。
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现任华中科技大学协和医院核医学科及教研室主任、分子影像湖北省重点实验室主任、生物靶向治疗教育部重点实验室副主任、华中科技大学医学影像系副主任。社会任职包括中华医学会核医学分会常委兼秘书长、中国核学会核医学分会副理事长、中国医学影...
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