网络释义 1. 范可尼贫血信号通路 人源细胞中存在一条专门应对这类突变的信号通路,被称为范可尼贫血信号通路(Fanconi anemia pathway)。该通路由一系列蛋 … cdmd.cnki.com.cn|基于 1 个网页
5.Fanconianemia pathway通路;范可尼贫血通路 6.FanconiSyndmme可尼综合征;合并范可尼综合征 7.fanconi´ s anemiafanconi贫血 8.de toni-fanconisyndrome德;范二氏综合征 用法例句 1. They renamed the protein FAN1, short forFanconianemia-associated nuclease 1. ...
Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13 Fanc genes. The disorder is characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs). A central event in the activation of the Fanconi anemia pathw...
BMC Cancer (2019) 19:1042 https://doi.org/10.1186/s12885-019-6305-x RESEARCH ARTICLE Open Access CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling Tamara Codilupi, Doreen Taube and Hanspeter Naegeli* Abstract Background: DNA-crosslinking agents like...
We found that human Cas9-induced SSTR requires the Fanconi anemia (FA) pathway, which is normally implicated in interstrand cross-link repair. The FA pathway does not directly impact error-prone, non-homologous end joining, but instead diverts repair toward SSTR. Furthermore, FANCD2 protein ...
Cell Biosci (2020) 10:39 https://doi.org/10.1186/s13578-020-00401-7 Cell & Bioscience REVIEW Open Access Fanconi anemia pathway as a prospective target for cancer intervention Wenjun Liu1, Anna Palovcak1, Fang Li1, Alyan Zafar1, Fenghua Yuan1* and Yanbin Zhang1,...
Several Fanconi anemia pathway members operate in other DDT pathways, e.g., the tumor suppressor proteins BRCA1 (also named as FANCS) and BRCA2 (also named as FANCD1), which, besides their primary roles in double-stranded DNA break repair, also control replication, transcription, and cell ...
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stressXinlin Xu, Yixi Xu, Ruiyuan Guo, Ran Xu, Congcong Fu, Mengtan Xing, Hiroyuki Sasanuma, Qing Li, Minoru Takata, Shunichi Takeda, Rong Guo & Dongyi Xu ...
Fanconi anemia (FA) is a rare genetic disorder characterized by aplastic anemia, cancer/leukemia susceptibility and cellular hypersensitivity to DNA crosslinking agents, such as cisplatin. To date, 12 FA gene products have been identified, which cooperat