网络释义 1. 范可尼贫血信号通路 人源细胞中存在一条专门应对这类突变的信号通路,被称为范可尼贫血信号通路(Fanconi anemia pathway)。该通路由一系列蛋 … cdmd.cnki.com.cn|基于 1 个网页
Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13 Fanc genes. The disorder is characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs). A central event in the activation of the Fanconi anemia pathw...
Several Fanconi anemia pathway members operate in other DDT pathways, e.g., the tumor suppressor proteins BRCA1 (also named as FANCS) and BRCA2 (also named as FANCD1), which, besides their primary roles in double-stranded DNA break repair, also control replication, transcription, and cell ...
We found that human Cas9-induced SSTR requires the Fanconi anemia (FA) pathway, which is normally implicated in interstrand cross-link repair. The FA pathway does not directly impact error-prone, non-homologous end joining, but instead diverts repair toward SSTR. Furthermore, FANCD2 protein ...
Fanconi是什么意思 网络范可尼; 范科尼; 范康尼 词组短语 1.Fanconisyndrome范可尼综合征;范科尼综合征;综合征;范科尼分析征 2.FanconiAnemia范可尼贫血;范科尼贫血;贫血症 3.Fanconianaemia尼贫血;范可尼贫血症 4.Lignac-Fanconi利 5.Fanconianemia pathway通路;范可尼贫血通路 ...
BMC Cancer (2019) 19:1042 https://doi.org/10.1186/s12885-019-6305-x RESEARCH ARTICLE Open Access CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling Tamara Codilupi, Doreen Taube and Hanspeter Naegeli* Abstract Background: DNA-crosslinking agents like...
Cell Biosci (2020) 10:39 https://doi.org/10.1186/s13578-020-00401-7 Cell & Bioscience REVIEW Open Access Fanconi anemia pathway as a prospective target for cancer intervention Wenjun Liu1, Anna Palovcak1, Fang Li1, Alyan Zafar1, Fenghua Yuan1* and Yanbin Zhang1,...
The Fanconi anemia (FA) pathway is a multigene DNA damage response network implicated in the repair of DNA lesions that arise during replication or after exogenous DNA damage. The FA pathway displays synthetic lethal relationship with certain DNA repair genes such as ATM (Ataxia Telangectasia Mutate...
2. The Fanconi anemia pathway Fanconi anemia (FA) is a pathologically diverse, recessively inherited disease that typically culminates in bone marrow failure in affected individuals. Patients also display profound genome instability that correlates with cancer predisposition and may have developmental defec...