Thus, our goal was to conduct a family based GWAS to identify genes across the genome that are associated with Class I malocclusion, as defined by molar relations, in humans with and without clefts. Methods: Our cohort consisted of 739 individuals from 47 Filipino families originally recruited ...
Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies have yet to identify statistically
To identify schizophrenia susceptibility genes, we applied a family-based GWAS strategy in an enlarged, ethnically homogeneous, Arab-Israeli family sample. We performed genome-wide single nucleotide polymorphism (SNP) genotyping and single SNP transmission disequilibrium test association analysis and found ...
ZNF804A has been implicated in susceptibility to schizophrenia by several genome-wide association studies (GWAS), follow-up association studies and meta-an... Satomi Umeda-Yano a,Ryota Hashimoto b c d,Hidenaga Yamamori a b,... - 《Schizophrenia Research》 被引量: 36发表: 2013年 加载更多来...
Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies have yet to identify statistically robust, replicated major effect genes or SNPs. ...
Imputation of parental genotypes, inference of sibling IBD segments, family based GWAS, and polygenic score analyses. - GitHub - AlexTISYoung/snipar: Imputation of parental genotypes, inference of sibling IBD segments, family based GWAS, and polygenic s
kidney disease 2, polycystic kidney and hepatic disease 1),CFC1(polysplenia),JAG1(Alagille syndrome) andPKD1L1(biliary atresia splenic malformation syndrome- BASM). We also did not find significant variants in the susceptibility loci ofADD3,XPNPEP1,GPC1,ARF6andEFEMP1,as suggested by GWAS44...
The analysis of genome-wide association studies (GWAS) poses statistical hurdles that have to be handled efficiently in order for the study to be successfu... A Murphy,ST Weiss,C Lange - 《Methods Mol Biol》 被引量: 9发表: 2010年 Family-based association tests: FBATs for various data ty...
We illustrate the application of the proposed method using data from the Cleveland Family GWAS Study. 展开 关键词: family-based association generalized estimation equations kernel machine regression marginal models score test variance component DOI: 10.1002/gepi.21763 被引量: 47 ...
et al. Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data. Transl Psychiatry 7 (2017). Bureau, A. et al. Inferring rare disease risk variants based on exact probabilities of sharing by multiple affected relatives. Bioinformatics ...