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A. Combined hyperlipidemia: familial but not (usually) monogenic. Curr. Opin. Lipidol. 27, 131–140 (2016). Google Scholar Haralambos, K. et al. Clinical experience of scoring criteria for Familial Hypercholesterolaemia (FH) genetic testing in Wales. Atherosclerosis 240, 190–196 (2015). ...
Familial hypercholesterolemia is a type of primary hyperlipidemia in which serum low-density lipoprotein cholesterol (LDL-C) levels are elevated. Familial hypercholesterolemia is a monogenic, autosomal dominant disorder caused by defects in the gene that encodes for the low-density lipoprotein (...
Treatment of hyperlipidemia with combined niacin–statin regimens. Am J Cardiol. 1998;82(12):82U–4. Article CAS PubMed Google Scholar Austin MA, Zimmern RL, Humphries SE. High “population attributable fraction” for coronary heart disease mortality among relatives in monogenic familial ...
They usually appear in patients with homozygous FH but can also occur in patients with familial dysbetalipoproteinemia, sitosterolemia, or cerebrotendinous xanthomatosis and rarely in secondary hyperlipidemias, such as nephrotic syndrome. Download: Download high-res image (167KB) Download: Download ...
Familial combined hyperlipidemia (FCHL) is characterized by elevated levels of serum total cholesterol (TC), triglycerides (TG), or both in affected family members. FCHL is estimated to be common with a prevalence of 1% to 2% in Western populations. Despite intensive research the genetic and ...
LDLClinical trialsHyperlipidemiaCoronary artery diseaseBackground: Familial hypercholesteremia (FH) leads to elevated low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (ASCVD). Although treatable, FH is underdiagnosed. Lipid lowering therapy may mask diagnostic pretreatment ...
leukocyte activationatherosclerosisLeukocyte activation is an obligatory factor in the development of atherosclerosis. The postprandial situation has been associated to increased leukocyte activation in several disorders, such as type 2 diabetes mellitus and familial combined hyperlipidemia. Our study aim was ...
Severe FCHL included: LDLc and TG > 90th percentile adjusted for age and sex, apolipoprotein B (apoB) > 150 mg/dL, body mass index (BMI) < 27.5 kg/m2 and at least one first-degree family member with mixed hyperlipidemia. Clinical exclusion criteria were: secondary causes ...
In addition to FCHL is characterized by variability of genotype, by the age dependence of the hyperlipidemia and by the lack of unequivocal diagnostic criteria. It is important to emphasize the need for a variety of approaches, both biochemical and genetic, and for studies of multiple populations...