CatsVirulent systemic diseaseSystemic calicivirus infectionTwo cats were admitted for skin lesions and lethargy. The first cat showed acute facial and limb crusting, pustular dermatitis, severe depression and poor appetite. The second cat showed crusting and hemorrhagic lesions on the nasal planum ...
The conversion of famciclovir to penciclovir may be inefficient in cats, and oral absorption to the active drug is approximately 10% in cats, and can be variable. Penciclovir has antiviral activity against herpes virus type 1 (HSV1) and 2 (HSV2). The action is related to the affinity ...
Animals--8 adult cats. Procedures--A balanced crossover design was used. Phase I consisted of a single administration (62.5 mg, PO) of famciclovir. Phase II consisted of multiple doses of famciclovir (62.5 mg, PO) given every 8 or 12 hours for 3 days. Plasma penciclovir concentrations ...
The proportion of cats in which FHV-1 DNA was detected increased over time in all cats in the pilot study. In the clinical trial, food intake and median clinical disease scores for nasal discharge and sneezing increased from days 1 to 7 in both groups and demeanor scores worsened in ...
Data to date in normal and experimentally infected cats suggest that the pharmacokinetics of this drug are extremely complex and likely result from nonlinear famciclovir absorption, metabolism, excretion, or an combination of these three factors.13,14 In spite this, there is mounting evidence that ...