血清lncRNA FAM83H-AS1在肺癌诊断中的临床价值初探.docx,血清lncRNA FAM83H-AS1在肺癌诊断中的临床价值初探 一、引言 随着医疗科技的飞速发展,对肿瘤疾病,特别是肺癌的诊断与治疗已取得显著的进步。肺癌的早期诊断与及时治疗对提高患者生存率和生活质量具有重要意义。而长
However, the expression status and function of FAM83H-AS1 in bladder cancer are still unknown. The object of our study is to explore the clinical value of FAM83H-AS1 in patients with bladder cancer and the biological function of FAM83H-AS1 in bladder cancer cells. In our results, the ...
The interactions between FAM83H-AS1, CDO1, and DNA methyltransferase1 (DNMT1) were analyzed by RNA-binding protein immunoprecipitation or chromatin immunoprecipitation assay. The xenograft mouse model was utilized to test CDO1 and FAM83H-AS1's influence on tumor development in vivo. Results showed ...
After publication, the authors became aware that their MHCC-97H and HCCLM3 cell lines were contaminated with HepG2, which affected the results of the FAM83H-AS1 overexpression experiment. The authors therefore no longer have confidence in the conclusions of this article. All authors agree to ...
基金 河南省科技攻关项目(222102310488) 河南省医学科技攻关联合共建项目(LHGJ20220794)。 关键词 lncRNA FAM83H-AS1 侵袭 子宫内膜癌 miR-485-5p 分类号 R737.33 [医药卫生—肿瘤] 登录即可查看详情 中国妇产科临床杂志 2024年 第5期 职称评审材料打包下载 ;...
结论FAM83H-AS1基因在乳腺癌中高表达,与患者的不良预后、临床病理分期、肿瘤微环境及TMB均有相关性。同时FAM83H-AS1与免疫检测点相关的一些基因及错配修复基因存在相关性,以上可能为临床乳腺癌的治疗、预测预后及基因靶向药物的研制提供理论依据。 【总页数】7页(P1-6) 【作者】李娜;袁军;张安志;胡楚玲;徐茂义 ...
FAM83H-AS1 has been identified as one of the LncRNAs that is dysregulated in multi-type cancers. Here, our purpose was to determine the expression pattern and clinical significance of FAM83H-AS1 and further analyse its prognostic value in colon cancer. FAM83H-AS1 expression was examined in 90...
长链非编码RNA FAM83H-AS1是一种新LncRNA,转录自邻近FAM83H基因对侧的8q24.3染色体.有阶段性研究发现FAM83H-AS1在许多癌症中表达水平都升高,其中包括结直肠癌,肺癌,胃癌,膀胱癌,宫颈癌,但其在肿瘤中发挥作用的分子机制尚不明确.为明确LncRNA FAM83H-AS1在乳腺癌细胞发生发展过程中的主要作用,初步查究其在肿瘤中...
FAM83H-AS1 silencing impairs two important breast cancer related pathways: cell migration and cell death. Among the most relevant potential FAM83H-AS1 gene targets, we found p63 and claudin 1 (CLDN1) to be deregulated after FAM83H-AS1 knockdown. Using correlation analysis, we show that FAM83H...
T4 (1770-2440 nt) and T5 (2440-2743 nt) on exon 4 of FAM83H-AS1 provide a platform for PTBP1 RRM2 interactions. Our results demonstrated that m6A modification dysregulated the FAM83H-AS1 oncogenic role by phosphorylated PTBP1 on its RNA splicing effect. In patient-derived xenograft models,...