FAM83A-AS1 was hypothesized as a predictor for the therapeutic effectiveness of thoracotomy. We evaluated its correlation with patient outcomes and its significance in predicting postoperative prognosis, with the aim of providing a reference to improve postoperative prognosis of thoracotomy. Materials and...
How does FAM83A influence lung cancer cell proliferation and invasion through the Wnt/β-catenin pathway? How does FAM83A regulate the Wnt signaling pathway in pancreatic cancer? In what way does FAM83A-AS1 contribute to the progression of Non–small Cell Lung Cancer (NSCLC)? How does FAM83...
Bioinformatics and dual-luciferase reporter gene experiments were performed to predict and verify the targeting relationship between FAM83A-AS1 and miR-150, and miR-150 and the high-mobility family protein A2 (HMGA 2). The expression of miR-150 and ...
CCK-8, transwell, apoptosis and cell cycle assays were performed to define the function of FAM83A-AS1 in ESCC cells. Furthermore, the regulation of miR-214 by FAM83A-AS1 was defined by qRT- PCR and rescue assays. In addition, the association between CDC25B, miR-214, CDC25B was ...
LncRNA FAM83A-AS1增殖迁移侵袭FAM83A目的 探讨长链非编码RNA序列相似家族83成员A-反义核糖核酸1(lncRNA FAM83A-AS1)在乳腺癌(breast cancer, BC)中的作用及潜在机制.方法 免疫组织化学(IHC)染色检测BC组织中FAM83A的表达;实时荧光定量PCR(qRT-PCR)检测BC组织/细胞中lncRNA FAM83A-AS1,FAM83A mRNA表达水平...
Long noncoding antisense RNA FAM83A-AS1 promotes lung cancer cell progression by increasing FAM83A: SHI et al.doi:10.1002/jcb.28336Rongxing ShiZichen JiaoAo YuTao Wang
临床病理特征预后目的 检测长链非编码RNA(lncRNA)序列相似家族83成员A-反义核糖核酸1(FAM83A-AS1)在肺腺癌(LU-AD)中的表达水平,探讨lncRNA FAM83A-AS1和LUAD患者临床病理学特征及预后的关系.方法 分析2015年1月至12月间80例行外科手术治疗的LUAD患者相关临床资料.采用Real-time PCR方法检测80例LUAD组织,并与...
Cell proliferation, migration, invasion, and autophagy were analyzed after knockdown FAM83A-AS1 with siRNAs. The underlying molecular mechanisms of FAM83A-AS1 were performed by Western blot, qRT-PCR, and RNA-seq analysis. We found that FAM83A-AS1 was up-regulated in lung cancer and elevated ...
Mechanistically, FAM83A-AS1 functions as an endogenous sponge of miR-150-5p by directly targeting it, removing inhibition of MMP14, a target of miR-150-5p. Furthermore, rescue assays demonstrated that FAM83A-AS1 enhances cell migration, invasion and EMT by modulating the miR-150-5p/MMP14 ...
However, the role of lncRNA FAM83A-AS1 in PC remains unclear. In this study, we explored the biological function and underlying mechanism of FAM83A-AS1 in PC cells.Methods: The FAM83A-AS1 expression was assessed via public databases and validated by qRT-PCR. The biofunction and immune ...