FAM46C, also known as terminal nucleotidyltransferase 5C (TENT5C), is initially recognized as a non-canonical polyadenylate ribonucleic acid polymerase and has been identified as a tumor suppressor in multiple myeloma. However, the function of FAM46C in other cancers is still unclear. Methods ...
TENT5C/FAM46C modulation in vivo reveals a trade-off between antibody secretion and tumor growth in multiple myelomaMassimo ResnatiSara PennacchioLisa VivianiTommaso PeriniMaria MaterozziUgo OrfanelliJessica BordiniRaffaella MolteniMario Nuvolone
Herein we demonstrate physical interaction of Plk4 with FAM46C/TENT5C, a conserved protein of unknown functionuntil recently. FAM46C localizes to centrioles, inhibits Plk4 kinase activity, and suppresses Plk4-induced centriole duplication. Interference with Plk4 function by FAM46C was ...
TENT5Cpoly(A) polymeraseautophagyPLK4tumour suppressormultiple myelomaFAM46C is a well-established tumour suppressor with a role that is not completely defined or universally accepted. Although FAM46C expression is down-modulated in several tumours, significant mutations in the ...
FAM46CTENT5Cgastric cancertumor suppressorbiomarkernorcantharidinOn a global scale, gastric adenocarcinoma (GCa) accounts for a large burden of death from cancer. Despite advances in systemic therapy and surgical technique, the fatality rate for GCa remains unacceptably high in Europe and North America...