目的 探讨中国汉族人群中与其他自身免疫性疾病相关的FAM167A-BLK和TNFSF4基因区域多态性是否与原发性干燥综合征(pSS)存在遗传相关性.方法 临床对照研究.选取2008年11月至2011年12月北京协和医院515例中国汉族pSS患者和567名健康体检者,对所有候选单核苷酸多态性 (SNP)位点采用时间飞行质谱生物芯片系统(Sequenom ...
Association of the FAM167A-BLK region with systemic sclerosis. Ito Ikue,Kawaguchi Yasushi,Kawasaki Aya,Hasegawa Minoru,Ohashi Jun,Kawamoto Manabu,Fujimoto Manabu,Takehara Kazuhiko,Sato Shinichi,Hara Masako,Tsuchiya Naoyuki. Arthritis and Rheumatism . 2010Ito I, Kawaguchi Y, Kawasaki A, Hasegawa M, ...
eQTL (expression quantitative loci) analyses in peripheral blood cells show a significantly increased expression of FAM167A for the disease associated genotypes. While BLK acts downstream of the B cell receptor, the function of FAM167A is unknown. Additionally, the role of the only homologous ...
A recent genome-wide study in a north American population showed new associations with rheumatoid arthritis (RA), among which was a single nucleotide polymorphism (SNP) rs2736340 in the intergenic region of BLK and FAM167A.5 In the HapMap Japanese samples (http://www.hapmap.org/index.html....
Sun F, Li P, Chen H, Wu Z, Xu J, Shen M, Leng X, Shi Q, Zhang W, Tian X, et al. Association studies of TNFSF4, TNFAIP3 and FAM167A-BLK polymorphisms with primary Sjogren's syndrome in Han Chinese. J Hum Genet 2013;58(7):475-479....
A recent genome-wide study in a north American population showed new associations with rheumatoid arthritis (RA), among which was a single nucleotide polymorphism (SNP) rs2736340 in the intergenic region of BLK and FAM167A.5 In the HapMap Japanese samples (http://www.hapmap.org/index.html....
While BLK (B lymphocyte kinase) has a well-established role in B cells, family with sequence similarity to 167 member A (FAM167A) and its gene family remain uncharacterized. To begin to understand the role of FAM167A in rheumatic disease pathogenesis, we explored this gene family and cloned ...
Single-nucleotide polymorphisms (SNPs) in the TNFSF4 and FAM167A-BLK genes have recently been shown to be associated with various immune-related disorders.Our aim was to determine whether TNFSF4 or FAM167A-BLK polymorphisms confer genetic susceptibility to asthma and AR in a Han Chinese population...
Introduction Genome-wide association studies of multiple autoimmune diseases, including Sjgren's syndrome, systemic lupus erythematosus and rheumatoid arthritis have identified associations in the FAM167A/BLK locus. eQTL (expression quantitative loci) analyses in peripheral blood cells show a significantly ...
Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjogren’s syndrome. Genes Immun. 2011;12:100–9.Nordmark G, Kristjansdottir G, Theander E, Appel S, Eriksson P, Vasaitis L et al (2011) Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene ...