Common side effects of fam-trastuzumab deruxtecan may include:nausea, vomiting, loss of appetite; diarrhea, constipation; cough; fever, feeling tired; low blood cell counts; low potassium; abnormal liver function tests; or hair loss.This is not a complete list of side effects and ...
This phase I trial tests the safety, side effects, and best dose of azenosertib in combination with trastuzumab deruxtecan in treating patients with HER2-positive and cyclin E amplified gastric or gastroesophageal junction cancer and other HER2-positive solid tumors that have spread to nearby tiss...
Common Generic Name(s): fam-trastuzumab deruxtecan-nxki Pronunciation: en-HER-too, FAM-tras-TOOZ-ue-mab DER-ux-TEE-kan Drug Classes: antibody-drug conjugate (ADC), antineoplastic; HER2-directed antibody and topoisomerase inhibitor conjugate, monoclonal antibody Availability: prescription only, no ...
(fam-trastuzumab deruxtecan-nxki) for injection What is the most important information I should know about ENHERTU? ENHERTU can cause serious side effects, including: Lung problems that may be severe, life-threatening or that may lead to death.If you develop lung problems your healthcare pro...
(fam-trastuzumab deruxtecan-nxki) for injection What is the most important information I should know about ENHERTU? ENHERTU can cause serious side effects, including: Lung problems that may be severe, life-threatening or that may lead to death.If you develop lung problems your healthcare pro...
1、HER2-阳性转移性乳腺癌(MBC):德曲妥珠单抗(Fam-trastuzumab deruxtecan-nxki)适用于治疗患有不可切除或转移性HER2-阳性乳腺癌症的成年患者,这些患者之前接受过基于抗HER2-的方案,包括在转移环境中,或在新辅助或辅助环境中,并且在完成治疗期间或六个月内出现疾病复发。
fam-trastuzumab deruxtecan-nxki是HER2定向的抗体-药物偶联物。该抗体是人源化抗HER2 IgG1。小分子DXd是拓扑异构酶I抑制剂,通过可裂解的接头与抗体连接。与肿瘤细胞上的HER2结合后,fam-trastuzumab deruxtecan-nxki通过溶酶体酶进行内在化和细胞内接头裂解。释放后,可透膜的DXd引起DNA损伤和凋亡细胞死亡。
全部名称:曲妥珠单抗重组冻干粉注射剂,Enhertu,fam-trastuzumab deruxtecan,fam-trastuzumab deruxtecan-nxki,DS8201 适应症: ENHERTU是一种针对HER2的抗体和拓扑异构酶抑制剂的偶联物,适用于治疗无法切除或转移性HER2阳性乳腺癌的成年患者,这些患者已在转移后接受了两种或多种先前的基于抗HER2的治疗方案。 用法用量...
通用名:fam-trastuzumab deruxtecan-nxki 研发代号:DS-8201 靶点:HER2 厂家:第一三共、阿斯利康 中国上市情况:否 获批适应症:1、2019年12月21日,ENHERTU获美国FDA批准用于治疗接受过2种或以上抗HER2疗法的无法切除或转移性HER2阳性乳腺癌患者;2、2021年1月15号,美国FDA批准ENHERTU(DS-8201)用于既往接受过曲妥珠...
Enhertu(fam-trastuzumab deruxtecan-nxki)(Enhertu; AstraZeneca,Daiichi Sankyo)是一种新型抗体-药物偶联物,具有三个成分:人源化抗HER2免疫球蛋白G1单克隆抗体,其氨基酸序列与曲妥珠单抗相同(Herceptin,Genentech);拓扑异构酶1抑制剂有效载荷;和基于四肽的可裂解接头。