Significant correlation between HSV IgM and SARS-CoV-2 IgM/IgG positivity was found. Adding 0.5% polyvinylpyrrolidone, inhibiting non-specific solid-phase adsorption, abolished interference in 22% of false positive cases, suggesting interference caused by solid-phase reactive IgM. Hence, serologic ...
Aside from glycoprotein-based vaccines, an EBNA-3 epitope-based vaccine was tested in 14 HLA B*0801-positive EBV-seronegative adults in a phase I trial140. This vaccine consisted of an EBNA-3 CD8+epitope (FLRGRAYGL) combined with tetanus toxoid as CD4+T cell helper and Montanide ISA 720 ...
Subsequent tests of CMV and HSV PCR for viral load were negative (VZV was not clinically suspected), and later on, EBV-EBNA returned negative and EBV-VCA IgM and IgG returned positive, confirming the diagnosis of acute EBV infection. Conclusion We believe that IgM seropositivity can result ...
Immunoglobulin (Ig) M antibodies to varicella zoster virus (VZV) as well as herpes simplex virus (HSV) were positive in the cerebrospinal fluid (CSF), whereas polymerase chain reaction of the CSF was positive for VZV-DNA but negative for HSV-DNA. The serum/CSF IgM ratio for VZV and HSV ...
false positive reactionsAntibody class capture assays (ACCA) with detergent-solubilized, peroxidaselabelled membrane antigens of infected and uninfected cells and indirect enzyme immunoassays (EIA) were compared for the detection of IgM antibodies to cytomegalovirus (CMV), herpes simplex virus (HSV) and...