结论:LIPUS体外照射可通过整合素-FAK-MAPK力化学传导通路抑制OA软骨细胞MMP-13的增高,减少Ⅱ型胶原及蛋白多糖的降解,从而对软骨细胞产生一定的保护作用. 展开 关键词: 低强度脉冲超声波 软骨细胞 整合素 FAK MAPK 学位级别: 硕士 学位年度: 2014 被引量: 5 ...
Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytesfocal adhesion kinasechondrocytemechanical stimulationmitogen-activated protein kinasesExcessive mechanical stimulation is considered an important factor in the destruction of chondrocytes. Focal adhesion ...
摘要:探讨普鲁卡因通过细胞外信号调节激酶(ERK)/丝裂原活化蛋白激酶(MAPK)/黏着斑激酶 (FAK)通路抑制骨肉瘤细胞增殖、迁移和侵袭过程。 目的探讨普鲁卡因通过细胞外信号调节激酶(ERK)/丝裂原活化蛋白激酶(MAPK)/黏着斑激酶 (FAK)通路抑制骨肉瘤细胞增殖、迁移和侵袭过程。 方法体外培养人骨肉瘤 Saos-2 细胞,分为对...
Inhibiting FAK or MAPK pathway could significantly ameliorate airway remodeling induced by excessive secretion of YKL-40 in vitro. and in vivo. In conclusion, this study shed light upon the effects of YKL-40 in asthma airway remodeling and provided potential novel targets in asthma patients with ...
3整合素β1-FAK-MAPKs信号通路相关蛋白表达:LIPUS干预使整合素β1、磷酸化FAK表达增高;同时MAPKs信号通路相关蛋白ERK1/2、p38磷酸化水平明显下降,而JNK磷酸化水平无明显变化。结论:LIPUS可以减轻骨性关节炎软骨ECM损伤程度,与LIPUS产生机械应力使关节软骨中细胞表面应力受体之一整合素β1及其下游分子黏着斑激酶FAK磷酸化...
Meanwhile, fibronectin enhanced cell proliferation, colony formation, migration, invasion, and angiogenesis, maintained stemness of NSCLC probably by activating FAK and MAPK/ERK signaling pathways, and elevating the HIF-1α. Then, activated HIF-1α bound to WISP3 promoter region, triggering the ...
本研究以二氧化钛纳米管阵列为形貌模型,发现了纳米形貌可通过Integrin β1/FAKpY397/MAPK通路抑制破骨分化,并改变巨噬/破骨细胞细胞因子的分泌谱从而促进了骨生成。这为全面理解纳米形貌对巨噬/破骨细胞的调控作用提供了重要参考。 Grap...
用Src阻断剂-PP2阻断Src,用MAPK阻断剂-UO126阻断MAPK,观察Src或MAPK被阻断后对ErbB2诱导的细胞移动和细胞转化的影响。结果:感染后ErbB2在FAK+/+细胞中稳定表达和激活。PP2抑制ErbB2诱导的FAK磷酸化以及ErbB2诱导的细胞移动。UO126阻断ErbB2诱导的MAPK磷酸化以及ErbB2诱导的细胞锚定依赖性生存-细胞转化。结论:ErbB2...
Meanwhile, the FAK/MAPK and PI3K/AKT pathways are two significant signaling pathways with the ability to induce cell proliferation and osteogenic differentiation, respectively [27], [28]. Our results indicated that Ti@PDA + SrHA strongly enhanced the phosphorylation level of FAK, ERK1/2, and ...
连接蛋白诱导FAK磷酸化的位 点不同,进一步证实del1-693FAK.GFP,dell一100FAK-GFP,抑制MAPK的磷酸化, 增强Akt的磷酸化;而FAK—GFP增 强MAPK磷酸化,抑制Akt磷酸化.结论FAK通过和EGFR的相互作用调节MAPK 和Akt之间的相对平衡. 【关键词】受体,表皮生长因子;整粘蛋白;MAPK;Akt ...