近日,应世生物科技(南京)有限公司(以下简称“应世生物”或“公司”)宣布,公司旗下黏着斑激酶(FAK)抑制剂IN10018治疗铂耐药卵巢癌获得美国FDA快速通道认定。应世生物拥有IN10018的全球专利权与开发权益。IN10018的快速通道认定表明了IN10018在治疗铂耐药卵巢癌这一在全球范围内存在着迫切未满足临床需求的疾病方面的巨大...
Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signalling and cell migration, but FAK can also promote cell survival in response to stress. FAK is commonly overexpressed in canc
OPA333AQDBVRQ1、OPA2349EA/3K、OPA548F/500、OPA4340UAG4、OPA4820IPWT、OPA364IDRG4、OPA380AIDRG4、OPA2196IDGKR、OPA4374AID、OPA4241PA、OPA2691I-14DRG4、OPA350EA/250、OPA2322AQDGKRQ1、OPA347UA、OPA544T、OPA2674I-14DR、OPA2677UG4、OPA316IDCKR、OPA2341DGSA/250、OPA322SAIDBVR、OPA627...
Nature 370, 341–347 (1994). Article ADS CAS PubMed Google Scholar Wieser, R., Wrana, J. L. & Massague, J. GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J. 14, 2199–2208 (1995). Article CAS...
In patients who underwent in vitro fertilization (IVF) and experienced repeated implantation failure, G-CSF treatment resulted in a marked increase in biochemical pregnancy rates (RR=212; 95% CI 154, 293), embryo implantation rates (RR=251; 95% CI 182, 347), and clinical pregnancy rates (...
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J Mol Biol, 2005, 347(5): 1005-1014. 3 Zhao J, Pestell R, Guan JL. Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell, 2001, 12(12): 4066-4077. 4 Wang JG, Miyazu M, Xiang P, et al. Stretch-induced cell proliferation is...
研究表明,黑米皮花青素(black rice anthocyanidins,BRACs)能够抗人表皮生长因子受体-2(human epidermalgrowth factor receptor-2,HER-2)阳性乳腺癌转移,但其抗转移效应机制目前尚不明确.上皮细胞-间充质转化(epithelialmesenchymal transition,EMT)是上皮细胞来源的恶性肿瘤细胞获得迁移和侵袭能力的重要生物学过程,而粘着...