近日,应世生物科技(南京)有限公司(以下简称“应世生物”或“公司”)宣布,公司旗下黏着斑激酶(FAK)抑制剂IN10018治疗铂耐药卵巢癌获得美国FDA快速通道认定。应世生物拥有IN10018的全球专利权与开发权益。IN10018的快速通道认定表明了IN10018在治疗铂耐药卵巢癌这一在全球范围内存在着迫切未满足临床需求的疾病方面的巨大...
Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signalling and cell migration, but FAK can also promote cell survival in response to stress. FAK is commonly overexpressed in canc
Nature 370, 341–347 (1994). Article ADS CAS PubMed Google Scholar Wieser, R., Wrana, J. L. & Massague, J. GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J. 14, 2199–2208 (1995). Article CAS...
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J Mol Biol, 2005, 347(5): 1005-1014. 3 Zhao J, Pestell R, Guan JL. Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell, 2001, 12(12): 4066-4077. 4 Wang JG, Miyazu M, Xiang P, et al. Stretch-induced cell proliferation is...
研究表明,黑米皮花青素(black rice anthocyanidins,BRACs)能够抗人表皮生长因子受体-2(human epidermalgrowth factor receptor-2,HER-2)阳性乳腺癌转移,但其抗转移效应机制目前尚不明确.上皮细胞-间充质转化(epithelialmesenchymal transition,EMT)是上皮细胞来源的恶性肿瘤细胞获得迁移和侵袭能力的重要生物学过程,而粘着...
同样情况也出现在用低剂量的一种FAK抑制因子处理过的正常小鼠身上。这与以下假设形成鲜明对比：FAK抑制...
347-367, 10.1016/j.ccell.2019.01.007 View PDFView articleView in ScopusGoogle Scholar 7 J.S. Desgrosellier, D.A. Cheresh Integrins in cancer: biological implications and therapeutic opportunities Nat. Rev. Cancer, 10 (2010), pp. 9-22, 10.1038/nrc2748 View in ScopusGoogle Scholar 8 G. ...