A pivotal transcriptional coregulator within cardiomyocytes is the PPAR-gamma coactivator (PGC-1α) which responds to a wide range of stimuli including starvation, exercise, and change in substrate availability. The downstream effector pathways of PGC1α are summarised in Fig. 2 and include PPARα...
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Systemic hypertension is an important comorbidity associated with heart failure due to its high prevalence in the general population. Chronic pressure overload leads to left ventricular hypertrophy, ventricular fibrosis, diastolic dysfunction, decreased left ventricular filling pressure, and eventually diastolic...
The risk of pulmonary morbidity and mor tcaalpitnyiac,oI,2rrealnadte, satwliethastthfeoreixntdeinvtidoufalhsywpeitrh restrictive pulmonary conditions, with dif ficulty in clearing airway secretions from inadequate peak cough expiratory flows (PCEFs) due to expiratory muscle weak ...
CPVT is triggered by physical exercise, and is related to leakiness of RyR2 channels and defective/downregulated FKBP12.6[20]. This condition can also be produced by ISO treatment[5]. This is likely due to an activated endothelin-1 (ET-1) system and oxidative stress[8]. As a result, ...
MPC serves as a crucial metabolic branch point that determines the fate of pyruvate in the cell, enabling metabolic adaptations during health, such as exercise, or as a result of disease. Decreased MPC expression in several cancers limits the mitochondrial oxidation of pyruvate and contributes to ...
In the course of testing, we eliminated 5 of 8 aMHC-Angptl2 Tg mice chosen for analysis as they were unable to sustain running due to exhaustion, whereas all WT littermates could perform the exercise (Supplementary Fig. 3g). These findings strongly suggest that cardiac remodelling in aMHC-...
and the heart has been shown to be able to oxidise more ketones per unit of mass than any other organ [89]. In contrast, during high intensity exercise (physiological hypoxemia) or ischaemia (pathological) there is a shift toward the more oxygen-efficient glucose and glycolytic ATP production...
Chronic heart failure (CHF) patients frequently experience impaired exercise tolerance due to skeletal muscle fatigue. Studies suggest that this in part is
(e.g. loss of more than 20% of body weight) had to be sacrificed (Fig.1a). 60 days after surgery, 65% of the heart failure mice had reached the end points, whereas none of the control (sham-operated) mice had (Fig.1a). Compared with the control mice, heart failure mice had a...