In addition, CD206 can adopt two different bend conformations, in which the CR and FNII domains are brought in proximity to CTLD3 and CTLD6, respectively [54]. These conformational changes appear to be pH-dependent, and may therefore play a role in ligand binding and release [54,55]. ...
Here we showed that although CD206 shedding in humans appear to be protease mediated, the release in humans is not mediated through the engagement of matrix metalloproteases unlike the shedding in mice [9]. Additionally, we have presented data suggesting that CD206, like CD163, also exists in...