Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative ...
Xia et al. [49] evaluated the utility of antibiotic-loaded bone cement combined with vacuum sealing drainage on DSWI, all patients’ healing wounds were first-stage healing without complications and reoperation. Federico et al. [50] found that in a high-risk patient population, the incidence ...
There was no difference between delivery methods of autologous BMSCs. These observations suggest that the provision of osteogenic cells alone is insufficient to enhance bone healing and that additional factors are required to initiate this process in vivo. 展开 ...
FOXO proteins are transcription factors that are involved in numerous physiological processes and in various pathological conditions, including cardiovascular disease, cancer, diabetes and chronic neurological diseases. For example, FOXO proteins are context-dependent tumour suppressors that are frequently inacti...
In the 1960s, a subtype of fibroblasts originating from bone marrow that possessed colony forming capacity and existed in almost all tissues was identified [1, 2]. These “fibroblasts” with the capacity to self-renew and differentiate were called mesenchymal stem cells (also named mesenchymal sto...
Researchers identify genetic factors that may aid survival from brain cancer by Henry Ford Health System A Henry Ford Hospital research team has identified specific genes that may lead to improved survival of glioblastoma, the most common and deadly form of cancerous brain tumor. The molecular dat...
Glutamine powder (5 grams 2x daily): Glutamine is an amino acid thathelps repairthe digestive tract, especially important for people with chronic diarrhea. It’s available in supplement form and also naturally in bone broth. Aloe vera juice(1/2 cup taken about 3x daily): Aloe is healing to...
Healing occurred in 32 of the 48 patients (67%) with skin lesions after a median delay of 45 days (range, 7 days to 18 months). Complete epithelialization of mucosal lesions was achieved in 27 of 50 patients (54%) after a median delay of 60 days (range, 7 days to 20 months). Of...
Also bone marrow derived mesenchymal stem/stromal cells (MSC) have been used as supportive treatment in HSC transplantation. The clinical experience with these therapies indicates that the i.v. administration of SSC did not reveal major health concerns, and is generally not accompanied by tumour ...
Objective: Clinicians have anecdotally noted that combat-related invasive fungal wound infections (IFIs) lead to residual limb shortening, additional days and operative procedures prior to initial wound closure, and high early complicati... T David,P Benjamin,L Louis,... - 《Open Forum Infectious...