Among low-and-middle-income regions, Europe and Central Asia had the highest proportion (39%) of deaths from cancer attributable to the risk factors studied. 1·6 million of the deaths attributable to these risk factors were in men and 0·83 million in women. Smoking, alcohol use, and ...
Mutated or dysregulated transcription factors represent a unique class of drug targets that mediate aberrant gene expression, including blockade of differentiation and cell death gene expression programmes, hallmark properties of cancers. Transcription factor activity is altered in numerous cancer types via ...
adj.+n. important factor,key factor,main factor,major factor,specific factor v.+n. consider factor,analyze factor,take factor,determine factor 英汉 英英 网络释义 n. 1. 【数】因子,因数;【物】系数,率;【生】遗传因子,基因;【化】当量换算因数;【摄】曝光系数 ...
Recombinant granulocyte-CSF (G-CSF) and granulocyte–macrophage-CSF (GM-CSF) have now been used to increase dangerously low white blood cell levels in many millions of cancer patients following chemotherapy. These CSFs also release haematopoietic stem cells to the peripheral blood, and these cells...
1. Family history of breast cancer Epidemiological investigations have found that 5% to 10% of breast cancers are familial. Especially if there is breast cancer among mothers or sisters, then this family belongs to the high-risk group, and the risk of the disease is two to three times higher...
In addition to tumor characteristics and lifestyle factors, cancer relapses are often related to the risk of death but have not been jointly studied. We investigate the prognostic factors of recurrent events and death after a diagnosis of breast cancer and predict individual deaths including a hist...
Factors that increase the risk of primary liver cancer include: Chronic infection with HBV or HCV. Chronic infection with the hepatitis B virus (HBV) or hepatitis C virus (HCV) increases your risk of liver cancer. Cirrhosis. This progressive and irreversible condition causesscar tissueto form in...
cancer, there are many things that increase your risk. Some people are more likely to get prostate cancer than others based on one or more gene variants they were born with. Lifestyle and other factors also play some role. Some of these risk factors you can change and others you can't....
This work was supported by the Stand Up To Cancer (SU2C) Convergence 2.0 Grant (M.S., A.C.C., C.S.M.), a collaboration by SU2C and the Society for Immunotherapy of Cancer; the SU2C Phillip A. Sharp Award for Innovation in Collaboration (grant number: SU2C-AACR-PS-22) (M.S....
We interpret the factors based on their association with recurrent molecular alterations, pathway enrichment, cancer type, and drug-response. Crucially, the cell line derived factors capture the majority of the relevant biological variation in Patient-Derived Xenograft (PDX) models, strongly suggesting ...