Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-off between the activity and specificity in human TFs encoded as submaximal dispersion of aromati...
M. Statistical studies of heart diseases; important factors in heart disease mortality trends. Public Health Rep. 63, 1247–1273 (1948). Article CAS PubMed Google Scholar Moriyama, I. M. & Gover, M. Heart diseases and allied causes of death in relation to age changes in the population....
Sandström, G., Marklund, E. Fertility differentials in Sweden during the first half of the twentieth century: the changing effect of female labor force participation and occupational field. Presented at the Annual Meeting of the Population Association of America, Chicago, 27–29 April 2017. Skak...
The human voltage-gated sodium channels (NaV) are a family of nine proteins (NaV1.1–NaV1.9) that are responsible for the generation and propagation of action potentials in excitable tissues throughout the human body. The functional core of each NaV is a single transmembrane pore-forming α-sub...
Diabetic nephropathy (DN) affects about 40% of diabetes mellitus (DM) patients and is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) all over the world, especially in high- and middle-income countries. Most DN has been present for years before it is...
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Regarding cancer biology, FOXO proteins acts downstream of several oncogenic pathways such as, PI3K–AKT, ERK and NF-κB-IKKβ (nuclear factor-κB and NF-κB kinase-β inhibitor, respectively) [39, 77, 81,82,83]. FOXOs have mostly been described as tumour suppressors as they possess anti-...
Distinct spatial and temporal expression patterns of two type I receptors for Bone Morphogenetic Proteins during mouse embryogenesis. Endocrinology 1995; 136:2652–63. Article CAS PubMed Google Scholar Mishina Y, Suzuki A, Ueno N, Behringer RR . Bmpr encodes a type I bone morphogenetic protein ...
S1); therefore, the estimated richness based on the RA matrix was strong enough to represent the diversity of chitons (Fig. S1). Chiton assemblages from the Peruvian Province had a comparatively high (and similar) diversity among localities, with around 7–12 species per site and higher ...