The article explains the incremental cost burden that is added to U.S. health payers by patients with atrial fibrillation (AF) and atrial flutter and who have more than one additional risk factor such as hypertension, diabetes or systemic embolism....
Together with recent work on enhancer elements, these results suggest an important evolutionary role of suboptimal features in transcriptional control. We propose that rational engineering of amino acid features that alter phase separation may be a strategy to optimize TF-dependent processes, including ...
We further demonstrate an antiviral role for membrane-anchored mucins in vitro and in mouse models of SARS-CoV-2 infection, and find that this antiviral activity extends to diverse respiratory viruses. Taken together, our bidirectional CRISPR screens dissect the densely interconnected landscape of pro...
Meaning Findings of this study suggest that racial differences in cardiovascular health are attenuated by varying experiences with neighborhood physical and social environments as well as by lived personal experiences with discrimination; approaches to improve ICH that target neighborhood factors and discrimina...
Regarding the correlation with treatment, prolongation of endocrine therapy was reported to contribute to an improvement in the long-term prognosis [6]. In addition, the ATLAS study also reported that long-term treatment (10 years) with tamoxifen (TAM) improved the long-term prognosis (>10 ...
After elimination of items that were not applicable for the current study, the modified quality checklist consisted of 11 items that could be scored with “Yes” (2), “partially” (1), or “No” (0). The items were added up to a total score ranging from 0 to 22 with higher values...
The role of youth problem behaviors in the path from child abuse and neglect to prostitution: a prospective examination. J Res Adolesc. 2010;20(1):210-236. doi:10.1111/j.1532-7795.2009.00624.x PubMedGoogle ScholarCrossref 36. Bruhns ME, del Prado A, Slezakova J,...
The median age at repair was 8 months (range, 36 days–18.5 months) with a median weight of 7.2 kg (range, 2.8-12). The spectrum of age ranges were less than 3 months (n = 12), 3 to less than 6 months (n = 20), 6 to less than 9 months (n = 21), and older than 9 ...
If the PRC government determines that the contractual arrangements constituting part of the VIE structure do not comply with PRC laws and regulations, or if these regulations or their interpretations change in the future, we could be subject to severe penalties or be forced to relinquish our ...
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distribute...